PDE7B

PDE7B

A gene on chromosome 6q23-q24 that encodes a cAMP-specific cyclic nucleotide phosphodiesterase, which hydrolyses the second messenger cAMP to AMP and thus has a role in regulating physiological processes.
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Insel, professor of pharmacology and medicine at the UC San Diego School of Medicine, has found that high levels of a enzyme, called PDE7B, in the blood are an indicator that chronic lymphocytic leukemia (CLL) - the most common form of adult leukaemia.
PDE7B controls the levels of cyclic AMP (cAMP), a molecule that can promote programmed cell death, a process that is defective in CLL.
The question was, could the level of PDE7B expression provide evidence for the clinical stage and diagnosis for individual patients?
During the study, Insel along with postodoctoral fellow Linghzi Zhang, compared the amount of PDE7B in white blood cells in 85 untreated patients with CLL to those of 30 healthy adults, and watched for changes over time.
We found that individuals with high levels really had worse disease and showed that PDE7B expression had predictive value relative to other currently available markers for disease severity and progression," Insel said.
In some cases, the level of PDE7B expression provided prognostic information that was additive to existing markers," he added.
Zhang said that PDE7B can be used alone as a biomarker for CLL if the levels are high enough, but may be used with other markers if the level is lower and ambiguous.
sapiens) hypothetical protein FLJ20489 243438_at PDE7B phosphodiesterase 7B Probe set ID p-Value Ratio (GM) 243296_at 0.