PDE7A | definition of PDE7A by Medical dictionary
PDE7A A gene on chromosome 8q13 that encodes a cyclic nucleotide phosphodiesterase, which hydrolyses the second messenger cAMP to AMP and is thus involved in regulating physiological processes. PDE7A is thought to have a role in signal transduction in muscle.
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References in periodicals archive
Four phosphodiesterases (PDE4D, PDE7A
, PDE7B, and PDE8B) and two adenylate cyclases (ADCY2, ADCY4) were upregulated, and adenylate kinase (ADK) and AMP deaminase 3 (AMPD3) were downregulated in stimulated versus unstimulated cells.
We also assessed the expression of PDE1 (isoforms PDE1A, 1B and 1C), and PDE10A, which hydrolyze both cAMP and cGMP, as well as the cAMP-specific PDE7 enzyme isoforms, PDE7A
, and PDE7B, whose presence in the brain is well documented [34-36].