PDE6D

PDE6D

A gene on chromosome 2q35-q36 that encodes a GTP-specific dissociation inhibitor, which markedly increases the affinity of ARL3 for GTP by decreasing nucleotide dissociation.
References in periodicals archive ?
At the level of cGMP/GMP and cAMP/AMP regulation, the downregulation of PDE6D and adenylate cyclase 7 (ADCY7) as well as the upregulation of PDE4B and two soluble forms of guanylate cyclase (GUCY1A3, GUCY1B3) suggest a shift towards cGMP and AMP production.
Ingenuity canonical pathways P value Affected molecules Phototransduction pathway 2.57E-04 ARR3, GRK1, and PDE6D The visual cycle 5.50E-04 RDH11, RDH12 RAR activation 1.00E-03 RDH11, ADCY1, RDH12, and CITED2 Retinoate biosynthesis I 2.69E-03 RDH11, RDH12 Retinol biosynthesis 2.69E-03 RDH11, RDH12 Creatine-phosphate biosynthesis 1.17E-02 CKMT1A/CKMT1B Protein kinase A signalling 1.26E-02 H3F3A/H3F3B, ADCY1, GRK1, and PDE6D NAD biosynthesis III 1.26E-02 Nmnat3 NAD biosynthesis from 1.62E-02 Nmnat3 2-amino-3-carboxymuconate semialdehyde NAD salvage pathway III 1.62E-02 Nmnat3