PDE4D

A gene on chromosome 5q12 that encodes a counterpart of the fruit fly “dunce” gene, which has 3',5'-cyclic-AMP phosphodiesterase activity and hydrolyses the second messenger cAMP to AMP, thereby playing a role in regulating physiological processes.

References in periodicals archive ?

Many hypotheses but no replication for the association between PDE4D and stroke.

C-reactive Protein −717A>G and −286C>T>A Gene Polymorphism and Ischemic Stroke

The generation of mice deficient in PDE4A, PDE4B, and PDE4D has been described previously.

Phosphodiesterase 4B is essential for lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages

Now, the same researchers have examined the effects of two selective PDE4D inhibitors, NVP-ABE171 and cilomilast, as anti-prostate cancer therapies in both in vitro and in vivo models.

MoBiTec GmbH: PDE Inhibitors Show Sonic Effects on Prostate Cancer

Symbol Entrez gene name PDE3A Phosphodiesterase 3A, cGMP-inhibited PIK3C2G Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma PDE11A Phosphodiesterase 11A MC4R Melanocortin 4 receptor PDE4D Phosphodiesterase 4D, cAMP-specific TAAR1 Trace amine associated receptor 1 CNR1 Cannabinoid receptor 1 (brain) RGS18 Regulator of G-protein signaling 18 ADRA2B Adrenoceptor alpha 2B CALCR Calcitonin receptor AVPR1A Arginine vasopressin receptor 1A ADCY2 Adenylate cyclase 2 (brain) Symbol Fold change Location Type(s) PDE3A 9.

Mechanism of action of Rhodiola, salidroside, tyrosol and triandrin in isolated neuroglial cells: an interactive pathway analysis of the downstream effects using RNA microarray data

Using a technique called fluorescent polarization, they found that all three components significantly inhibited PDE4D.

Ginger may help alleviate asthma symptoms

ALOX5AP gene and the PDE4D gene in a Central European population of stroke patients.

Candidate genetic risk factors of stroke: results of a multilocus genotyping assay

Antidepressant-like profile and reduced sensitivity to rolipran in mice deficient in the PDE4D phosphodiesterase enzyme.

El futuro de la farmacoterapia antidepresiva *

4 204924_at TLR2 4q32 227613_at ZNF331 223454_at CXCL16 17p13 228962_at PDE4D 214696_at MGC14376 17p13.

Discovery of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzene-exposed workers

The discovery of the gene, PDE4D, will not lead to immediate treatments, however the gene produces an enzyme that can be targeted with drugs.

Icelandic researchers find gene linked to stroke

However, the gene, PDE4D, produces an enzyme that can be targeted with drugs, suggesting future therapies are possible.

Vaccine against pancreatic cancer moves step closer following trials

PDE4D plays a role in phosphodiesterase activity in skeletal muscle (Fleming-Waddell et al.

Validation of single nucleotide polymorphisms associated with carcass traits in a commercial Hanwoo population

hydronephrosis Imipramine ADRA18, ADRA1D Renal nephritis Imipramine TP53, NOS1, CTNS, ALB, NFKB2, VDR, PDE4D, PPP3CA, ACE Heart failure lmipramine EPO, NOS1, ATP1A3, CACNA1D, ACCN3, KCNG2, PDE4D, SLC9A1, TTN, ADRB3, KCNJ11, ADRA1D.

Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine