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Many hypotheses but no replication for the association between PDE4D and stroke.
The generation of mice deficient in PDE4A, PDE4B, and PDE4D has been described previously.
Now, the same researchers have examined the effects of two selective PDE4D inhibitors, NVP-ABE171 and cilomilast, as anti-prostate cancer therapies in both in vitro and in vivo models.
Symbol Entrez gene name PDE3A Phosphodiesterase 3A, cGMP-inhibited PIK3C2G Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma PDE11A Phosphodiesterase 11A MC4R Melanocortin 4 receptor PDE4D Phosphodiesterase 4D, cAMP-specific TAAR1 Trace amine associated receptor 1 CNR1 Cannabinoid receptor 1 (brain) RGS18 Regulator of G-protein signaling 18 ADRA2B Adrenoceptor alpha 2B CALCR Calcitonin receptor AVPR1A Arginine vasopressin receptor 1A ADCY2 Adenylate cyclase 2 (brain) Symbol Fold change Location Type(s) PDE3A 9.
Using a technique called fluorescent polarization, they found that all three components significantly inhibited PDE4D.
ALOX5AP gene and the PDE4D gene in a Central European population of stroke patients.
Antidepressant-like profile and reduced sensitivity to rolipran in mice deficient in the PDE4D phosphodiesterase enzyme.
4 204924_at TLR2 4q32 227613_at ZNF331 223454_at CXCL16 17p13 228962_at PDE4D 214696_at MGC14376 17p13.
The discovery of the gene, PDE4D, will not lead to immediate treatments, however the gene produces an enzyme that can be targeted with drugs.
However, the gene, PDE4D, produces an enzyme that can be targeted with drugs, suggesting future therapies are possible.
PDE4D plays a role in phosphodiesterase activity in skeletal muscle (Fleming-Waddell et al.
hydronephrosis Imipramine ADRA18, ADRA1D Renal nephritis Imipramine TP53, NOS1, CTNS, ALB, NFKB2, VDR, PDE4D, PPP3CA, ACE Heart failure lmipramine EPO, NOS1, ATP1A3, CACNA1D, ACCN3, KCNG2, PDE4D, SLC9A1, TTN, ADRB3, KCNJ11, ADRA1D.
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