PDE4D

A gene on chromosome 5q12 that encodes a counterpart of the fruit fly “dunce” gene, which has 3',5'-cyclic-AMP phosphodiesterase activity and hydrolyses the second messenger cAMP to AMP, thereby playing a role in regulating physiological processes.

References in periodicals archive ?

BPN14770 is a novel therapeutic agent that selectively inhibits phosphodiesterase-4D (PDE4D) to enhance early and late stages of memory formation.

Tetra Discovery Partners partners with Shionogi & Co Ltd for BPN14770 in Japan, Korea and Taiwan

Five of these 12 genes had increased 5-hmC peaks by BPA exposure--Grb10, Pde10a, phosphodiesterase 4D (Pde4d), Plagl1, and Gnas.

Longitudinal Effects of Developmental Bisphenol A Exposure on Epigenome-Wide DNA Hydroxymethylation at Imprinted Loci in Mouse Blood

A potential difference in tumor cellularity of the tissue punches was addressed by normalization of the qPCR results of the PDE4D transcript to four reference genes which were selected based on stable gene expression across multiple tumor sample types [18].

The Prognostic PDE4D7 Score in a Diagnostic Biopsy Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes

Some of these genes include Apolipoprotein E (APOE), methylenetetrahydrofolate reductase (MTHFR), Endothelial Nitric Oxide Synthase (ENOS), Factor V Leiden (F5), Cytochrome P450 4F2 (CYP4F2), beta-fibrinogen, and Phosphodiesterase 4D (PDE4D).

Stroke in the 21st Century: A Snapshot of the Burden, Epidemiology, and Quality of Life

Four phosphodiesterases (PDE4D, PDE7A, PDE7B, and PDE8B) and two adenylate cyclases (ADCY2, ADCY4) were upregulated, and adenylate kinase (ADK) and AMP deaminase 3 (AMPD3) were downregulated in stimulated versus unstimulated cells.

Transcriptional Profiling Suggests Extensive Metabolic Rewiring of Human and Mouse Macrophages during Early Interferon Alpha Responses

They found that phosphodiesterase 4D (rs702553) was significantly associated with the female patient group, and PDE4D gene polymorphisms could cause susceptibility for the development of ISSHL in the southern Taiwanese female population.

Studying the Association between Sudden Hearing Loss and DNA N-Methyltransferase 1 (DNMT1) Genetic Polymorphism

In addition, heterozygous mutations in PRKAR1A, which encodes the regulatory subunit of protein kinase A (PKA) and PDE4D, which encodes phosphodiesterase type 4, have been found in patients with acrodysostosis (40,41,42).

Current Nomenclature of Pseudohypoparathyroidism: Inactivating Parathyroid Hormone/Parathyroid Hormone-Related Protein Signaling Disorder

Many hypotheses but no replication for the association between PDE4D and stroke.

C-reactive Protein −717A>G and −286C>T>A Gene Polymorphism and Ischemic Stroke

Other PDE4 isoforms expressed in macrophages (PDE4A and PDE4D) were not involved in the regulation of this response.

Phosphodiesterase 4B is essential for lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages

Conti, "PDE4D and PDE4B Function in Distinct Subcellular Compartments in Mouse Embryonic Fibroblasts," J.

Role of PDE4 isoforms in regulating camp compartmentalization and pulmonary microvascular endothelial cell (PMVEC) barrier permeability

Goettingen, Germany, October 02, 2014 --(PR.com)-- In a paper published in 2009, researchers led by Paul Marker at UW-Madison, identified Phosphodiesterase 4D (PDE4D) as a novel proliferation-promoting factor in prostate cancer.

MoBiTec GmbH: PDE Inhibitors Show Sonic Effects on Prostate Cancer

This increased airway hyperresponsiveness is causally related to decreased lung cAMP levels, increased PDE4 enzymatic activity, and PDE4D isoform-specific mRNA expression in the lung [11].

Effects of inactivated Bordetella pertussis on phosphodiesterase in the lung of ovalbumin sensitized and challenged rats