In fact, in dyslipidemic mouse models, niacin downregulates genes involved in insulin (such as INSR and PDE3B
) and B-adrenergic (such as B-1,2,3-AR) signaling pathways , whereas prolonged treatment enhances B-AR responsivity [147, 148].
Our recent observation suggests that PPAR[gamma] activation in adipogenesis that can be blocked by treatment with cPA participates in adipocyte function through inhibition of PDE3B expression .
Chung et al., "From PDE3B to the regulation of energy homeostasis," Current Opinion in Pharmacology, vol.
Insulin receptor, leptin, ObRa, and phosphodiesterase 3B (PDE3B
) were similar between groups (data not shown).
For example, miR-128 has 6 predicted gene targets [pyruvate dehydrogenase kinase, isozyme 1 (PDK1); pyruvate dehydrogenase kinase isozyme 2 (PDK2); MTOR; phosphodiesterase 3A, cGMP-inhibited (PDE3A); phosphodiesterase 3B, cGMP-inhibited (PDE3B
); FOXO1], and miR-141 is predicted to target 5 genes [PTEN; PDK2; cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A); CDKN1B;PDE3B].