PDE11A

PDE11A

A gene on chromosome 2q31.2 that encodes a cyclic nucleotide phosphodiesterase, which hydrolyses cAMP to 5’-AMP and cGMP to 5’-GMP, downregulating cAMP and cGMP signalling. 

Molecular pathology
PDE11A mutations may cause Cushing disease and adrenocortical hyperplasia.
References in periodicals archive ?
Symbol Entrez gene name PDE3A Phosphodiesterase 3A, cGMP-inhibited PIK3C2G Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma PDE11A Phosphodiesterase 11A MC4R Melanocortin 4 receptor PDE4D Phosphodiesterase 4D, cAMP-specific TAAR1 Trace amine associated receptor 1 CNR1 Cannabinoid receptor 1 (brain) RGS18 Regulator of G-protein signaling 18 ADRA2B Adrenoceptor alpha 2B CALCR Calcitonin receptor AVPR1A Arginine vasopressin receptor 1A ADCY2 Adenylate cyclase 2 (brain) Symbol Fold change Location Type(s) PDE3A 9.
Previous studies by NIH researchers have linked genetic variations that inactivate PDE11A with increased susceptibility to testicular cancer and adrenal tumours.
The researchers found that a group of men with prostate cancer were nearly four times more likely to have variations affecting the activity of PDE11A than did men who did not have prostate cancer.
Our study indicates that PDE11A one day may have a place in genetic screening for predisposition to prostate cancer," said senior author of the study, Constantine Stratakis.
Highlighted papers at the event include PDE11A (ICOS Corporation), PDE3A knockout mice (NIH), PDE10A (Pfizer), and Novel PDE4A Isoforms (U.
The researchers found that seven different mutations in the gene in question, PDE11A, created abnormal versions of the PDE11A enzyme that slowed down the enzyme's destruction of cyclic AMP.
Stratakis and his colleagues analyzed the portion of the DNA from 95 familial testicular cancer patients that contains the PDE11A gene.
Stratakis said that learning how disruptions in the PDE11A enzyme lead to an increased risk of tumor formation may help researchers identify other proteins that also play a role.