"Our results in this study, while not providing direct evidence of causality, nonetheless suggest a significant and positive impact of the PCV13 vaccination program on otitis media for children less than 5 years of age in the U.S., with further reductions in OM visits observed in PCV13 period following a decade of PCV7
Three isolates had serotypes included in PCV7
, whereas nine isolates did not.
(ix) in the base model, ST3 IPD in adults is not influenced by PCV use in children, but sensitivity analyses were performed, considering serotype 3 as a nonvaccine type (positively influenced by PCV7
and PCV13 use) or as a PCV13-7 type (negatively influenced by PCV13 use);
In a study of privately insured children in the USA, a 41.9% reduction in antibiotic prescriptions for AOM was demonstrated from 1997 to 2004 following implementation of the PCV7
immunisation programme. It has been predicted that universal vaccination of children with PCV13 would reduce AOM by an additional 16.3 million cases in the USA compared with vaccination with PCV7
, firstly introduced in 2000 in USA, was recommended as a part of routine childhood immunization by the WHO in 2007.
Compared with PCV7
years, the rate after introduction of PCV13 was 27% lower, indicating 1.5 fewer hospitalizations per 1,000 children.
In a phase 4, observational, database safety study of PCV7
, Kawasaki disease was not significantly more frequent than in a historic control group after adjustment for race, sex, and other factors (29).
vaccine has now been replaced with a newer pneumococcal vaccine called PCV13, which works in the same way as PCV7
but protects against more strains of Streptococcus pneumoniae bacteria.
Soon after PCV7
was included in the routine child immunization schedule, the incidence of invasive pneumococcal disease (IPD) began to decline.
These trials used the vaccination schedule at 6, 10 and 14 weeks, without a booster dose, and a PCV made by the same manufacturer as PCV7
, but additionally containing serotypes 1 and 5 (PCV9) was used.