PCSK7


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PCSK7

A gene on chromosome 11q23-q24 that encodes a ubiquitous endoprotease of the peptidase S8 family involved in the constitutive secretory pathway that cleaves the RXXX(K/R)R consensus motif. It is localised intracellularly to the trans Golgi network and is expressed in the spleen, thymus, prostate, testes, ovaries, small intestine, colon and peripheral leukocytes.
References in periodicals archive ?
Qi et al., "PCSK7 genotype modifies effect of a weight-loss diet on 2-year changes of insulin resistance: the pounds lost trial," Diabetes Care, vol.
Risk factors Proposed mechanisms and pathophysiology Increased transferrin saturation Increased iron entry into beta and transport via transferrin cells of islets receptors Elevated nontransferrin bound iron in plasma and entry by Increased iron transport by divalent metal transporter 1 Islet inflammation Decreased insulin secretion Beta-cell injury Pancreatic islet fibrosis Associated with severe iron Cirrhosis overload, pancreatic fibrosis Hyperglucagonemia PCSK7 rs236918 allele C History of diabetes in Multiple genetic and acquired first-degree relatives factors Genetic markers Multiple loci for type 2 diabetes Chromosome 6p loci for type 1 (autoimmune) diabetes