PCSK6A gene on chromosome 15q26.3 that encodes a broadly active endoprotease of the peptidase S8 family involved in the constitutive secretory pathway in both neuroendocrine and non-neuroendocrine tissues. It cleaves the RX(K/R)R consensus motif. Each PACE4/PCSK6 isoform (PACE4A-I, PACE4A-II, PACE4B, PACE4C, PACE4D, PACE4E-I and PACE4E-II) has a unique restricted distribution.
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