PCSK6

PCSK6

A gene on chromosome 15q26.3 that encodes a broadly active endoprotease of the peptidase S8 family involved in the constitutive secretory pathway in both neuroendocrine and non-neuroendocrine tissues. It cleaves the RX(K/R)R consensus motif. Each PACE4/PCSK6 isoform (PACE4A-I, PACE4A-II, PACE4B, PACE4C, PACE4D, PACE4E-I and PACE4E-II) has a unique restricted distribution.
References in periodicals archive ?
The researchers then made full use of knowledge from previous studies of what PCSK6 and similar genes do in mice to reveal more about the biological processes involved.
The most strongly associated, statistically significant, variant with handedness is located in the gene PCSK6, which is involved in the early establishment of left and right in the growing embryo.
Disrupting gene PCSK6 in mice causes 'left-right asymmetry' defects, such as abnormal positioning of organs in the body.
ASPN and coagulation factor V (F5) were assayed on multiplexed bead set B and PCSK6 on multiplexed bead set C.
We identified 7 novel biomarkers as statistically significant in discriminating protein concentrations in blood from men with advanced prostate cancer compared to controls: APOC1, ASPN, COMP, CXCL11, CXCL9, F5, and PCSK6.