PCSK5

PCSK5

A gene on chromosome 9q21.3 that encodes a broadly active endoprotease of the peptidase S8 family involved in the constitutive and regulated secretory pathway. It cleaves the RX(K/R)R consensus motif and plays an essential role in establishing pregnancy through the proteolytic activation of key factors, such as BMP2 and CALD1.
References in periodicals archive ?
Despite that no link to reported pathways was identified for the 15 ASC-specific proteins, several of them have a known immune function (S100 A13 protein, CCL2, LGMN, FUCA1, and METRNL) and/or are involved in neuron death and apoptosis (CCL2, CLU, LGMN, and PCSK5).
These genes includes AKAP13, AMER2, BBX, CEP97, CYP46A1, DPP3, DUSP2, GLIS3, GNB2, KLHL31, KMT2E, L1CAM, MINK1, NLN, PCSK5, PFKFB3, PHF6, PRPF38B, RB1, RGS7BP, RSF1, SEMA4C, SLC35F3, SLITRK2, SNX17, TNKS1BP1, TNPO1, and ZBTB41.