Evolution of the function of the kidney graft The glomerular filtration rate (GFR) using CKD-EPI was evaluated after one month, six months, one year, and three years as well as after a final registered follow-up, showing non-significant differences among the three groups (LN, PCKD, DN) (Fig.
The median GFR using CKD-EPI after three years of follow up was 62 mL/min/1.73 (SD: 19.4) in patients with LN, 56.4 mL/ min/1.73 (SD: 20.8) in PCKD and 66.9 mL/min/1.73 (SD: 18.16) in DN (p = 0.17) (Fig.
Some differences were observed when grouping by ESRD etiology, as more frequent risk of graft thrombosis in the PCKD group, more frequent risk of infection of the surgical wound, Cytomegalovirus (CMV) infections and delayed graft function in the DN group, and more frequent urinary infections in the LN group were observed.
8%/person-year) in the DN group (13 due to death, two from an infection and one acute rejection); and five (rate of 4.2%/person-year) in the PCKD group (one due to acute rejection, one due to a vascular cause and three due to death).
As our main finding, significant differences were not observed in the patient or graft survival rates among the groups (DN, LN and PCKD).
Differences were not significant in the outcome of the PCKD group compared with those in the other two groups.
In our study, patient survival was lower in the DN population than in the LN and PCKD groups (a 75.5% survival after three years in the DN group vs 87.5% in the LN group and 81.8% in the PCKD group); however, this difference was not statistically significant possibly due to the small sample size of the LN and PCKD groups.
In turn, age, the number of HLA incompatibilities, time in dialysis, time in cold ischemia, type of immunosuppression therapy and the disease causing ESRD (LN, PCKD and DN) did not affect graft survival.
Nonetheless, although the sample size may have affected our results, a slight significant difference was observed with graft thrombosis, which was higher in PCKD patients, however was no found an answer for this; infections on the surgical wound which was higher in diabetics, it is explained because diabetic group has more risk for infection diseases; and urinary infections which was higher in lupus patients because it often presented in women, and feminine gender is a risk factor for urinary tract infection.
In order to know the true prognosis in LN KT patients, it was compared it with DN KT because they have bad prognosis, and also we compared with PCKD KT patients because they have better prognosis.