PCDHA4

PCDHA4

A gene on chromosome 5q31 that encodes a putative calcium-dependent cell-adhesion protein, which may be involved in establishing and maintaining specific neuronal connections in the brain.
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In an independent cohort test, the methylated PCDHA4 and PCDHA13 test is equally sensitive but more specific than the human papillomavirus (HPV) test in the diagnosis of [CIN2.sup.+] [71].
More than 20 genes, including CADM1/MAL, PAX1, SOX1, ZNF582, PCDHA4, and PCDHA13, have been confirmed to be associated with the lesions of CIN2 and greater.
Gene Product Otoa NM_139310 Otoancorin Cabp2 NM_013878 Calcium binding protein 2 Sod3 NM_011435 Superoxide dismutase 3 Hspb8 NM_030704 Heat shock protein 8 Hsf5 NM_001045527 Heat shock transcription factor member 5 Otof NM_031875 Otoferlin Calca NM_007587 Calcitonin/calcitonin-related polypeptide alpha Pcdha4 NM_007766 Protocadherin alpha 4 Gene Symbol Fold Change p-Value Otoa +3.4 0.04 Cabp2 +1.6 0.003 Sod3 +2.0 0.03 Hspb8 +1.3 0.02 Hsf5 +1.8 0.02 Otof -1.8 0.04 Calca -1.9 0.04 Pcdha4 -1.3 0.001 Table 2.