New data show that the herbal supplement PC SPES contained even more contamination than was recognized when the product was abruptly pulled from store shelves early this year.
Detailed analysis using gas chromatography and mass spectroscopy has shown that some lots of PC SPES marketed between 1996 and 2001 contained varying levels of not only warfarin and DES, but also indomethacin.
Our serial lot analyses found that PC SPES lots manufactured from 1996 through the middle of 1999 contained indomethacin and diethylstilbestrol and that lots manufactured from the middle of 1999 through August 2001 contained progressively lower amounts of both substances and also had correspondingly decreased antineoplastic activity and estrogenicity," said Dr.
The origin of the three potent synthetic drugs in PC SPES is puzzling," Dr.
Available since November 1996, PC SPES had shown considerable promise in early studies and its antitumor potential had been extensively studied.
But by the summer of 2001, rumors of untoward effects and possible adulteration of PC SPES began circulating among prostate cancer patient groups.
PC SPES was researched and developed by combining principles of Chinese and Western medicine," said the developer of PC SPES, Dr.
A detailed analysis using gas chromatography and mass spectroscopy has shown that some lots of PC SPES marketed between 1996 and 2001 indeed contained varying levels of not only warfarin and DES, but also indomethacin.
PC SPES was on the market for over 5 years before the contamination was uncovered.
, capsules containing a light brown powder marketed for ``prostate health,'' contains warfarin, a powerful blood thinner often sold under the brand name Coumadin, California health officials said.