PBX3

PBX3

A gene on chromosome 9q33.3 that encodes a nuclear protein belonging to the PBX homeobox family of transcriptional factors.
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One study showed that PBX3 is a potential pathologic cofactor of HOXA9 involved in cytogenetically abnormal acute myeloid leukemia (CA-AML), particularly MLL-rearranged AML.
Li et al., "PBX3 is an important cofactor of HOXA9 in leukemogenesis," Blood, vol.
Several partners of EWSR1 are described: POU5F1 (6p21.33) (16%), PBX1 (16%), PBX3, ZNF444, ATF1, KLF17, and NFATC2 [10-16].
Biological Gene number Partial related methylated genes function Adhesion 580 Sox-2, Shh, Itpkb, Pkd1, Reln, Ptk2b, Nck2, Ass1 Lphn1, Cdh9, Epdr1, Myf5, Pdpn, Has2, Fgfrl1, Fer Secretion 553 Lphn1, Pim3, Fst, Pim3, Pcsk6, Lax1, Sct, Sytl3 Plcd1, Ykt6, Jak1, Stat2, Myc, Csf2, Lifr, Sos1 Proliferation 787 Dixdc1, Lrp6, Edn3, Nkx2, Cyr61, Src, Sox8, Stk4 Ephb1, Sstr3, Rrm2, Tcf3, Grn, Rhoa, Apc, Nox4, Strn Neuronal 473 Bhlhb9, Cckar, Fzd2, Thy1, Pbx3, regeneration Otx2, Lhx8, Btg2 Klhl1, Dlg2, Pak1, Wnt3, Mif, Tctn1, Evl, Ext1, Als2 Axonal 215 Ifrd1, c-Jun, Bcl2, Tnn, Mbp, Slit3, regeneration Ist1, Drgx, Thy1 Unc5c, Ntrk2, Isl1, Ptk2, Dscam, Atl1, Dnm2, Cxcl12 Figure 3: (a) The distribution of differentially methylated regions (DMRs) peaks in different components of genome.
Tenders are invited for the work consists of upgrading the existing voice/telephone infrastructure, which consists of two hosts (pbxl and pbx8) and five remote pbxs (pbx3, 4, 5, 6, 7) with new pbx systems.
PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells.
miRNA Expression level Cellular process miR-181a Upregulated by morphine Promote astrocyte-preferential differentiation of NSPCs miR-23b Upregulated by morphine Adult neurogenesis miR-190 Downregulated by fentanyl Adult neurogenesis miR-143 Upregulation by IGF-1 Promotes proliferation, neural differentiation, and cell survival miR-181c Upregulation by IGF1/LIF Enhanced self-renewal of NSPCs miRNA Molecular target Reference miR-181a Prox1/Notch2 [159] miR-23b Morphine receptor expression (MOR1) [160] miR-190 NeuroD [161] miR-143 PDGFRA, PRKCE, MAPK7, DSSP, DMP-1, [162] KRAS, and BCL-2 miR-181c PTPN11, PTPN22, PTEN, Dusp6, PBX3, ZEB2, [162] and IRF8