PBX1


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PBX1

A gene on chromosome 1q23 that encodes a nuclear protein belonging to the PBX homeobox family of transcriptional factors, which regulates osteogenesis and is required for skeletal patterning and programming.
 
Molecular pathology 
A translocation t(1;19) involving PBX1 and TCF3/E2A is associated with acute pre-B-cell lymphoblastic leukaemia; the resulting fusion protein, in which the DNA-binding domain of E2A is replaced by the PBX1 DNA-binding domain, upregulates gene transcription.
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References in periodicals archive ?
Humphries, "Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny," Experimental Hematology, vol.
KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells.
PBX1 The Pbxl-HoxC8 heterocomplex causes androgen-independent growth in prostate cancer (53).
In a series of mouse transplantation experiments, they found that six--H1f, Runx1t1, Pbx1, Lmo2, Zfp37 and Prdm5--of the 36 factors, plus two additional factors not originally identified in their screen--Mycn and Meis1--were sufficient to robustly reprogram two kinds of blood progenitor cells (pro/ pre B cells and common myeloid progenitor cells) into iHSCs.
MEIS1, which encodes a homeobox protein belonging to the TALE "three amino acid loop extension" family of homeodomain-containing proteins, as well as MEIS2 and PBX1 are found to have a critical function to suppress prostate cancer initiation and progression [21].
E2A, including its MTG16-interacting region, can be pathologically fused to other TFs (PBX1 and HLF1).