In this study, we investigated the pharmacokinetics of the two tracers by in vivo PBPK
modelling and studied the effects of transporter inhibition by cyclosporine on the pharmacokinetics of [[sup.11]C]MT107.
To study this, a PBPK
model was built using the Simcyp Advanced Dissolution Absorption and Metabolism (ADAM) model.
In this study, integrated modeling of a CSP with numerical Virtual Airway, which had been adapted to predict air flow and contaminant distribution around the human body, was developed to include PBPK
modeling in the respiratory tract.
Additional aspects include bioanalytical method development for Tox species and human (perhaps including key metabolites); documentation regarding toxicokinetics/exposure documentation (such as that involving safety pharmacology, genetic toxicology and repeated-dose toxicology)and human PK prediction (including bioavailability, allometric scaling and physiologically based pharmacokinetic (PBPK
modelling and simulation systems, and lots of research related to those, as well as research bringing input parameters for these predictive systems.
Physiologically based pharmacokinetic (PBPK
) modeling may help to distinguish sex differences in dermal absorption, body size, and toxicity (2,142) from gendered exposures.
In addition, physiologically based pharmacokinetic (PBPK
) models are being developed to provide for the ability to conduct route-to-route extrapolations, evaluate nasal uptake to the CNS, and evaluate lifestage differences in Mn pharmacokinetics.
Using these estimates, a PBPK
model-based algorithm computes the infusion rate profile for any desired BrAC exposure to be achieved during the experiment (for details of algorithm, please see Ramchandani et al.
With the aid of powerful computers, Ramsey and Andersen (120) took into account more realistic considerations of physiologic processes and developed a class of models known as physiologically based pharmacokinetic (PBPK
) models (120).
Pharmacokinetics of toxic chemicals in breast milk: use of PBPK
models to predict infant exposure.
The system uses physiologically based pharmacokinetic, or PBPK
, mathematical models to translate exposure levels into the amount of internal dose received and the resulting health risk.
- In-Vivo animal models & physiologically-based PBPK