PAX8

PAX8

A protein product of one of the PAX family of genes. It is used clinically as a biomarker of follicular thyroid cancer.
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Transcription gene mutations proven to be associated with thyroid dysgenesis are PAX8, TTF-2, NKX2.
13) Of other markers, the lesion is positive for IMP3 and PAX8, and negative for PAX2.
In our patient, P63, CK7, CK20, 34[beta]E12, and INI 1 were negative in immunohistochemical studies and PAX8 and CK19 were positive.
Immunohistochemical stains on the core biopsy showed the tumour cells were positive for TTF-1, PAX8, CK7 and occasional cells were positive for thyroglobulin.
2006) PAX8-peroxisome proliferator-activated receptor gamma (PPARgamma) disrupts normal PAX8 or PPARgamma transcriptional function and stimulates follicular thyroid cell growth.
1,3) Malfunctioning of the transcription factors TITF1/NKX2-1, PAX8, HHEX, and FOXE1 is highly related to ETT.
They observed that the cysts lined epithelial cells and the clear tumor cell clusters were positive for epithelium markers like CKpan (19/19), EMA (16/19) and CK7 (15/19), CA-IX (17/19) and PAX8 (15/19), and a low percentage staining for CD10 (7/19).
1) Como tal, el cancer de tiroides es una enfermedad multifactorial modulada por factores geneticos asi como ambientales, de los factores de riesgo ambientales destaca la deficiencia de yodo y dentro de las mutaciones geneticas destacan cambios puntuales, asi como la alteracion en la expresion de oncogenes como RAS hasta un 40% de casos y en los genes PAX8 y PPAR[gamma].
Expression of PAX8 in nephrogenic adenoma and clear cell adenocarcinoma of the lower urinary tract: evidence of related histogenesis?
Specifically, the SLITRK1 gene is associated with Tourette's syndrome, and the PAX8 gene is linked to hypothyroidism.
Specifically, the SLITRKI gene is associated with Tourette's syndrome, and the PAX8 gene is linked to hypothyroidism.
Biocare's portfolio of immunohistochemistry (IHC) and molecular pathology products includes a wide array of primary antibodies like p63, ERG and a monoclonal PAX8, as well as kits used by hospitals, reference and research laboratories worldwide.