PAX5

PAX5

A gene on chromosome 9p13, of which there are multiple isoforms, of which PAX-5A is most studied. It encodes 50-kD B-cell specific activator protein (BSAP), which is expressed in pre-B and mature B cells, but is downregulated/silenced during terminal differentiation of plasma cells under the influence of B-lymphocyte-induced maturation protein-1 (PRDM1). PAX-5A influences the expression of other B-cell specific genes, including CD19 and CD20 and CD79a, preceding the expression of CD20.
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Acute myeloid leukemia with t(8;21) often expresses the B-cell markers CD19, CD79a, and PAX5, which is associated with transcriptional upregulation of the PAX5 gene.
demonstrated that PCNSLs were targeted by aberrant somatic hypermutations with involvement of 4 potent proto-oncogenes – MYC, PAX5, PIM1, and Rho/TTF – all of which play an important role in differentiation, proliferation, and apoptosis of B-cell.
Se utilizaron los anticuerpos para CD3, CD79a, MUM1, PAX5 y lisozima para inmunohistoquimica.
Naphthol-AS-D-Chloroacetate Esterase (NASD), CD3, CD4, CD20, CD30, PAX5, LCA, Ki67, p53, LMP-1, and Bcl-6 stainings were also performed from the bone marrow and lymph nodes as well as the skin lesion.
After applying a protein block (10 minutes), a standard immunohistochemistry (IHC) technique was performed with prediluted mouse monoclonal antibodies TIA-1 (clone TIA-1), PAX5 (clone BC-24), CD7 (clone LP15), CD4 (clone BC/1F6) + CD8 (SP16) rabbit monoclonal antibody (prediluted double stain cocktail), or rabbit polyclonal antibody CD3.
It showed nodular pattern of mixed cellularity type of Hodgkin lymphoma characterized by background of eosinophils, plasma cells and lymphocytes, some Reed-Sternberg cells (classic or mononuclear forms) with prominent large eosinophilic nucleoli (positive for CD15, CD30 and weakly PAX5, negative for S100, CD1a, CD20 and CD45), accompanied by LCH with diffuse neoplastic proliferation of Langerhans cells in other part (figure 2).
The immunohistochemistry staining results showed these cells to be CD30+ (strong and diffuse); CD15 and PAX5 were positive in a few of these cells.
IMMUNOHISTOCHEMISTRY (IHC): Neoplastic lymphoid cells were CD 20, PAX5, CD10 and Bcl2 positive and Kappa light chain restriction.
Los LBDCG expresan marcadores pan B como CD19, CD20, CD22, CD79a y PAX5.
In all study participants, one of the two copies of the PAX5 gene was
The inherited genetic mutation is located in a gene called PAX5, which is known to play a role in the development of some B cell cancers, including ALL.
The single slide test aids the assessment of nine antibodies, namely CD30, CD15, CD20, CD45, PAX5, OCT2, BOB1, CD3 and CD79A, on a single formalin fixed paraffin embedded tissue section.