PAX2

PAX2

A gene on 10q24 that encodes a human homologue of Drosophila melanogaster gene prd. This family of transcription factor genes have a conserved DNA-binding paired box domain. PAX2 is thought to be a target of transcriptional suppression by the tumour suppressor gene WT1.

Molecular pathology
PAX2 mutations cause optic nerve colobomas and renal hypoplasia. PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.
References in periodicals archive ?
13) Of other markers, the lesion is positive for IMP3 and PAX8, and negative for PAX2.
FSGS can also be caused by genes that are widely expressed in other tissues and cell types and cause syndromic FSGS like WT1, PAX2 and LMX1B.
i) Clear cell adenocarcinoma (CCA): CCA usually occurs in women; it lacks clinical characteristics of adenoma; CCAs tend to be very large tumours; microscopically CCAs exhibit mostly clear cells; there is marked atypia in CCAs; there is muscularis propria invasion in CCA; there is additionally high mitotic rate in CCA; there is necrosis in CCA; there is high Ki-67 percentage in CCA; in CCA, usually PAX2 is negative (even though distinction is usually made upon morphologic grounds); CCA exhibits strong staining with p63 [22-24].
The investigators were able to differentiate both human ES cells and human iPS cells into cells expressing PAX2 and LHX1, two key markers of the intermediate mesoderm.
This process is directed by the genes PAX2 (Paired box 2), BMP-7 (Bone morphogenetic protein 7) (12), and WT1 (Wilms tumor) (13).
Renal coloboma syndrome is inherited autosomal dominantly and PAX2 is the only gene known to be associated with RCS (4).
36,37) PAX2 geninin mutasyonu ise optik sinir kolobomu olusmasi ile iliskilidir.
They identified a regulatory molecule called PAX2 that helps tamoxifen work by switching off a cancerpromoting gene.
Carroll said developing tests that doctors can use on a regular basis to determine if women have low levels of the protein, called PAX2, or high levels of a competing protein, known as AIB-1, are still at least five years away.
Scientists identified a regulatory molecule called PAX2 that helps tamoxifen work by switching off a cancer-promoting gene.
Additionally, Xp11 translocation RCCs consistently express CD10 and RCC marker, and the majority express PAX2 and PAX8.
PAX2 and PAX8 staining were also negative which helped rule out a malignancy of kidney origin.