PAX2

PAX2

A gene on 10q24 that encodes a human homologue of Drosophila melanogaster gene prd. This family of transcription factor genes have a conserved DNA-binding paired box domain. PAX2 is thought to be a target of transcriptional suppression by the tumour suppressor gene WT1.

Molecular pathology
PAX2 mutations cause optic nerve colobomas and renal hypoplasia. PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.
References in periodicals archive ?
Diagnostic utility of PAX8 and PAX2 immunohistochemistry in the identification of metastatic mullerian carcinoma in effusions.
6 Dressler GR, Deutsch U, Chowdhury K, Nornes HO, Gruss P: Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system.
Since PAX2 and PAX8 are expressed in both tumors, they do not help in the differential diagnosis (37,38).
Immunohistochemistry (IHC) showed positive cytokeratin (CK) 18, vimentin, PAX2, PAX8, and focal CD10 staining [Figure 2]b, [Figure 2]c, [Figure 2]d and negative staining for CK 7, CK 20, CD56, synaptophysin, and chromogranin A.
PAX2 and PAX8 expression in primary and metastatic Mullerian epithelial tumors: a comprehensive comparison.
("The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns") determine that Pax2, Sox2, and Prox1 have differential and overlapping temporospatial expression patterns during the development of vestibular and auditory sensory organs in mice.
Uterine congenital anomalies have a heterogeneous genetic basis, with implications of Wilms tumour 1 gene (WT1), paired box gene 2 (Pax2), WNT2, pre-B-cell leukemia transcription factor 1 (PBX1), and homeobox (HOX) genes [6].
The CAIX, PAX8, PAX2, CD10, and RCC demonstrate restricted expression in CCRCC but not in angiosarcomas.
Rohr, "Zebrafish hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors," Developmental Biology, vol.
Within the neural epithelial-derived optic vesicle, animal studies have demonstrated that Pax6 acts together with additional transcription factors such as Pax2, Six6, Gsx2, Pax5, and Lhx2 to regulate invagination to form the bilayered cup that will become the retina, retinal pigmented epithelium, and iris pigmented epithelium [8, 10, 12, 46].
The mRNA expression of WT-1, Pax2, and Pax8 was downregulated by CsA treatment.
Role of Pax genes in eye evolution: a cnidarian PaxB gene uniting Pax2 and Pax6 functions.