PARP


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PARP

Poly(ADP-ribose) polymerase. Any of a group of enzymes (five have been identified—PARP1–5) whose prototypic member (PARP1) is encoded by PARP1 on chromosome 1q41-q42. PARP1 detects and repairs single strand breaks in chromosomal DNA, and plays a key role in initiating DNA repair. High levels of PARP1 are associated with increased apoptosis in response to genotoxic stress, and it may act downstream of the Raf-MEK-ERK pathway through direct interaction with ERK2 in the nucleus, repairing DNA damage. PARP inhibitors are being explored as therapies for cancer, diabetes, stroke and cardiovascular disease.
References in periodicals archive ?
Also, under this patent, AsiDNA and the PARP inhibitor may be present in one combined dosage form, or as a part of separate dosage forms for sequential administration of the respective drugs.
The PARP family of enzymes hold a vital role in the repair of DNA and the stabilization of the human genome through the repair of single-stranded breaks (SSB) in DNA.
Poly(ADP-ribose) polymerase-1 (PARP) is the major isoform of an enzyme family, with multiple regulatory functions.
With a national executive board composed of hard-boiled retired professionals, the PARP met with the presidents of the Social Security System and Government Service Insurance System and introduced itself as a representative of SSS and GSIS retirees formed to coordinate with these agencies in matters affecting their interests as former members.
As many as eight PARP inhibitors are currently being developed, and major companies have invested millions of pounds in clinical trials.
Recent studies have suggested that triple-negative breast cancer patients might harbor genetic mutations that make them more likely to respond to alternative treatments such as cisplatin, a chemotherapy agent, or PARP inhibitors, anti-cancer agents that inhibit the poly (ADP-ribose) polymerase (PARP) family of enzymes.
Cross-link repair, translesion polymerases, the p53 gene, cell cycle checkpoints, BRCA1 and BRCA2, PARP and PARP inhibitors are also discussed as intervention targets.
BMN 673, which is yet to be given a trade name, is one of a handful of a family of molecules called PARP inhibitors which are under development for the treatment of cancer.
High level of ROS induces DNA strand breaks in the retina by hyperglycemia 22], and ROS-induced DNA single-strand breakages were considered an obligatory step for Poly(ADP-ribose) polymerase (PARP) cleavage/activation.
The relationship between PARP-1 activity and inflammation has been investigated for a long time with pharmacological PARP inhibitors and subsequently confirmed in PARP-1KO mice [5, 6].