UCHL1

(redirected from PARK5)

UCHL1

A gene on chromosome 4p14 that encodes a ubiquitin-protein hydrolase, involved both in processing of ubiquitin precursors and ubiquitinated proteins, which recognises and hydrolyses a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds free monoubiquitin and may prevent its degradation in lysosomes.
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References in periodicals archive ?
Clinical exome sequencing considering 4800 human genes including 18 genes related to Parkinson's disease (PARK1: SNCA; PARK2: PRKN; PARK3: SPR; PARK4: SNCA Dup/Del; PARK5: UCHL1; PARK6: PINK1; PARK7: DJ1; PARK8: LRRK2; PARK9: ATP13A2; PARK10: ELAVL4; PARK11: GIGYF2; PARK12: TAF1; PARK13: HTRA2; PARK14: PLA2G6; PARK15: FBXO7; PARK16: ADORAI; PARK17: VPS35; PARK18: EIF4GI) (TruSight One Sequencing Panels, Illumina) were performed on MiSeq platform (Illumina).
The textbook by Park5 considers EE/CEA as quantitative method based on behavioural sciences.
For example, ubiquitin E3 ligase (parkin, PARK2) and ubiquitin C-terminal hydrolase 1 (UCH-L1, PARK5) are critical for protein degradation via the ubiquitin-proteasome system (UPS).