SNCA

(redirected from PARK4)

SNCA

A gene on chromosome 4q21 that encodes alpha synuclein, which may be involved in regulating dopamine release and transport. SNCA induces fibrillisation of microtubule-associated protein tau, reduces neuronal responsiveness to apoptotic stimuli, and downregulates caspase-3.
References in periodicals archive ?
7) Sin embargo, la identificacion de mutaciones en ocho genes diferentes (SNCA, (8) PARK, (9) UCHL, (10) DJ1, (11) PINK, (12) LRRK2, (13) HTRA2 (14) y MAPT (15)) y de otras seis regiones cromosomicas candidatas (PARK, (16) PARK4, (17) PARK9, (18) PARK10, (19) PARK11 (20) y PARK12 (21)) asociadas con la enfermedad resalta la importancia etiologica de los factores geneticos.
Familiar SNCA/PARK1 32 UCHL1/PARK5 10 PARK3 16 PARK4 17 Dominante LRRK2/PARK8 13 MAPT 15,36 PARK10 19,35 PARK11 20 PARK2 9,33,34 PINK1/PARK6 37 Recesivo DJ1/PARK7 11,38 PARK9 18 PARK12 21 HTRA2/PARK13 14 Tabla no.