PARK2

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PARK2

A gene on chromosome 6q25.2-q27 that encodes a protein that functions within a multiprotein E3 ubiquitin ligase complex, catalysing the covalent attachment of ubiquitin moieties onto substrate proteins—e.g., BCL2, SYT11, CCNE1, GPR37, STUB1, SEPT5, ZNF746 and AIMP2. It also participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating polyubiquitination of misfolded proteins. PARK2 may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis; it may have tumour suppressor activity.

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Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population.

Is nullity for Glutathione S-transferase genes GSTT1 and GSTM1 protective against leprosy?

The PARK2 gene codes for a protein called parkin, which is hypothesized to target proteins for enzymatic degradation.

Understanding Parkinson Disease: a complex and multifaceted illness

They identified that the gene PARK2 was implicated in people with degenerate discs and could affect the speed at which they deteriorate.

Gene behind lower back pain identified

27-29) Las mutaciones en PARK2 comprenden un amplio espectro, incluyendo deleciones y duplicaciones de exones, ademas de diferentes tipos de mutaciones puntuales que afectan a los doce exones del gen.

Una mutacion en el gen PARK2 causa enfermedad de Parkinson juvenil en una extensa familia colombiana

Genes involved in neuronal cell adhesion (including NRXN1, CNTN4, NLGN1, ASTN2) were enriched with copy number variation in ASD cases, compared with controls, as were genes involved in ubiquitin degradation (including UBE3A, PARK2, RFWD2, and FBXO40).

Studies shed light on genetic variants in ASDs

Early onset PD or familial PD (occurring in people under 50 years of age) is less common, and recent data has identified some nuclear genes associated with familial PD, like LRRK2, PARK2, SNCA, PARK7, and PINK1 [104].

Melatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms

In the UK study, the researchers looked at 4,600 people and found that the PARK2 gene was linked to age-related disc problems.

Gene flaw 'may be behind low back pain'

We designated the gene, formerly known as parkin, as PARK2 (7) [parkinson protein 2, E3 ubiquitin protein ligase (parkin)] (3).

Parkin and Parkinson disease

Eight of these 12 highly associated SNPs were within or proximate to known genes {ADDS [adducin 3 (gamma)1, CD47 (CD47 molecule), RPS6KA2 (ribosomal protein S6 kinase, 90kDa, polypeptide 2), KLF6 (Kruppel-like factor 6), PARK2 [parkinson protein 2, E3 ubiquitin protein ligase (parkin)), MSRA (methionine sulfoxide reductase A), NRSNI (neurensin 1), and NRXNI (neurexin 1)} that likely interact through three networks (Figure 1) predicted by multiple binary protein--protein interactions as statistically associated in the curated published literature (Brennan a al.

Single-nucleotide polymorphisms associated with skin naphthyl-keratin adduct levels in workers exposed to naphthalene

Susceptibility to leprosy is associated with PARK2 and PACRG.

Development of amouse food pad model for detection of sub clinical leprosy

This methodology identified a promoter region shared by PARK2 also denoted as parkin and PACRG (parkin co-regulated gene).

Genetics of host response in leprosy

Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy," Autophagy, vol.

Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease