GPR172A

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GPR172A

A gene on chromosome 8q24.3 that encodes a riboflavin transporter, which also acts as a receptor for porcine endogenous retrovirus subgroup A (PERV-A).
References in periodicals archive ?
CagA-mediated inactivation of PAR1, which perturbs microtubule stability, causes microtubule-based spindle dysfunction, leading to prophase/ metaphase delay and subsequent misorientation of spindle formation.
2014) Natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1.
Intramolecular interaction, mediated between the N-terminal binding sequence (NBS) in Domain III and the C-terminal binding sequence (CBS) in the disordered C-terminal tail, potentiates binding capability of the tail with SHP2 and PAR1 via the EPIYA motif and CM motif, respectively, thereby strengthening the pro-oncogenic scaffold function of CagA.
CagA binds to PARlb as well as other PAR1 family members via the Cterminal CM motif.
Before a traumatic event, PAR1s usually tell amygdala neurons to remain active and produce vivid emotions.
When PAR1 was switched off at the onset of sepsis, 60 percent the mice survived.
In mice that had had sepsis for 4 hours, PAR1 indeed seemed to reverse its role.
In a separate set of experiments, the researchers found that activation of both PAR1 and a sister receptor, PAR2, is necessary for these cells to restore the lining.
They engineered thrombin to promote activity toward protein C - the anticoagulant target protein - and minimize activity toward fibrinogen and PAR1 - the procoagulant and prothrombotic targets.
We wanted to optimize this mutant to completely abrogate activity toward fibrinogen and PAR1.