GLI3

(redirected from PAPB)
Also found in: Wikipedia.

GLI3

A gene on chromosome 7p13 that encodes a DNA-binding C2H2-type zinc finger protein of the Gli family, which plays a role in limb development. The full-length GLI3 (GLI3FL) is a transcriptional activator; GLI3R, the C-terminally truncated form, acts as a repressor of the sonic hedgehog (Shh) pathway.

Molecular pathology
GLI3 mutations are associated with Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, pre-axial polydactyly type IV, and postaxial polydactyly types A1 and B.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Uhlin, "Regulatory cross-talk between adhesin operons in Escherichia coli: Inhibition of type 1 fimbriae expression by the PapB protein," EMBO Journal, vol.
The velocity profiles are weakly affected by the PAPB interaction at low grafting density, but become more sensitive to the PA-PB interaction at high grafting density.
Other proteins which play an important role as regulatory proteins include PapB, cAMP receptor protein (CRP) and H-NS.