PAPA syndrome


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Related to PAPA syndrome: SAPHO syndrome

PAPA syndrome

(pah'pah sin'drōm),
An autosomal dominant syndrome consisting of pyogenic sterile arthritis, pyoderma gangrenosum, and acne.
A rare autosomal dominant [MIM 64416] condition characterised by the acronym PAPA:
pyogenic arthritis
pyoderma gangrenosum and
cystic acne
Lab Hypogammaglobulinaemia, elevated tumour necrosis factor-alpha
Management Intra-articular corticosteroid therapy, methotrexate, colchicine
References in periodicals archive ?
PAPA syndrome not only affects Lily's joints but her immune system is severely affected too, so the slightest infection could have serious consequences.
Pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH)-a new autoinflammatory syndrome distinct from PAPA syndrome.
Doctors had struggled for years to pinpoint the precise problem and the Thornaby youngster underwent countless tests and operations before finally being diagnosed with PAPA Syndrome.