PAK3

PAK3

A gene on chromosome Xq23 that encodes a PAK protein of the serine/threonine p21-activating kinase family, which serve as targets for the small GTP-binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. PAK3 forms an activated complex with GTP-bound RAS-like (P21, CDC2 and RAC1) proteins that then catalyses various targets; it may be necessary for dendritic development and for the rapid cytoskeletal reorganisation in the dendritic spines associated with synaptic plasticity.

Molecular pathology
PAK3 mutations cause non-syndromic mental retardation X-linked type 30/47 (MRX30/47).
References in periodicals archive ?
Some of the potential targets of miR-302b-3p identified in humans (TargetScanHuman 7.1) are MAP3K2, BCL6, CCND2, CCND1, FGF10, RADA2, SMAD2, PAK3, and TGFfiR2 [13].
Malaysia bt Iran One 4-0 (83-53, 63-40, 61-17, 78-13), Pak3 bt India1
Among neural-derived cells, integrated mRNA-miRNA functional analyses of mature neurons (MNs), neural progenitor cells (NPCs), and neuroblastoma cells (NBCs) revealed that several very highly expressed genes (e.g., Robo1, Nrp1, Epha3, Unc5c, Dcc, Pak3, and Limk4) and a few underexpressed miRNAs (e.g., miR-152, miR-146b, and miR-339-5p) in MNs are associated with one important cellular process-axon guidance; some very highly expressed mitogenic pathway genes (e.g., Map2k1, Igf1r, Rara, and Runx1) and underexpressed miRNAs (e.g., miR-370, miR-9, and miR-672) in NBCs are associated with cancer pathways [23].
PAK also has two major isoforms, PAK1 and PAK3, and they have downstream signalling effects on Rho/Rac (for review see [61]).