PAK1


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PAK1

A gene on chromosome 11q13-q14 that encodes a PAK protein of the serine/threonine p21-activating kinase family, which are key effectors that link RhoGTPases to cytoskeletal reorganisation and nuclear signalling. PAKs serve as targets for the small GTP-binding proteins Cdc42 and Rac; PAK1 regulates cell motility and morphology.
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Our previous study showed that curcumin down-regulated the kinase activity of PAK1 to inhibit invasiveness of gastric cancer cells, and PAK1 was originally identified as a protein interacting with Racl (Kumar et al.