Maruta, "Herbal therapeutics that block the oncogenic kinase PAK1
: a practical approach towards PAK1-dependent diseases and longevity," Phytotherapy Research, vol.
Candidate target genes of hsa-miR-424-5p and hsa-miR-377 Gene name Main pathway Target Accession gene ID hsa-miR-424-5p Hypoxia and angiogenesis HIF1A MIRT005926 CUL2 MIRT005927 Cell cycle CDK6 MIRT000938 CCND1 MIRT000941 CCNE1 MIRT000936 CCND3 MIRT000937 hsa-miR-377 MAPK pathway PPM1A MIRT000990 PI3K-akt pathway PAK1
MIRT000991 HIF1A: Hypoxia-inducible factor 1A; CUL2: Cullin 2; CDK: Cyclin-dependent kinase; CCND1: Cyclin D1; CCNE1: Cyclin E1; CCND3: Cyclin D3; MAPK: Mitogen-activated protein kinase; PPM1A: Protein phosphatase magnesium-dependent 1A; PI3K: Phosphatidyl inositol 3'-kinase; PAK1
: p21-activated kinase 1.
A connection weight cutoff of 0.5 was used to identify 2 hub genes, cysteine-rich PAK1
inhibitor (CRIPAK) and forkhead box P4 (FOXP4).
Bokoch, "Membrane targeting of p21-activated kinase 1 (PAK1
) induces neurite outgrowth from PC12 cells, " EMBO Journal, vol.
They saw that in response to drug-induced DNA damage in a melanoma cell, RhoJ activated another gene, Pak1
, which initiated a molecular cascade suppressing the cell's ability to sense this damage - and blocking the apoptosis process.
Effective neurofibromatosis therapeutics blocking the oncogenic kinase PAK1
. Drug Discov Ther 2011;5:266-78.
A whole world if you ask British Asian business man, Abdul Rahim who is reclaiming the word Paki after he saw the licence plate of the Pakistani High Commissioner's car, PAK1
He sits in his shop in Peterborough, Cambs, with the slogan PAK1
writ large across his chest and the Star and Crescent emblem - a symbol of the Islamic faith - on everything from bags to beanie hats.
showed that miR-30c overexpression attenuated high-glucose-induced cardiomyocyte hypertrophy by inhibiting the expression of cell division control protein 42 homolog (Cdc42) and p21-activated kinases (PAK1
miRNA ID Target genes miR-26a TAB2, NLK, MEF2C, PAK1
miR-10b MAX, MEF2C, RAP1A let-7a-5p FLNA, NGF, FAS, MEF2C, CASP3, RASGRP1 let-7f FLNA, NGF, FAS, MEF2C, CASP3, RASGRP1 let-7i FLNA, NGF, FAS, MEF2C, CASP3, RASGRP1 miR-27b EGFR, TAB2, NLK, NF1, FAS, STMN1, MEF2C, GRB2 miR-191 BDNF Table 4: Target genes regulated by differentially expressed miRNAs in TGF-[beta] signaling pathway miRNA ID Target genes miR-708 THBS1 miR-21-3p TGIF1, SP1 miR-409a PITX2, BMPR2 miR-335 DCN, FST, THBS1, RBL1, ACVR2A, LTBP1, BMPR2 miR-224 SMAD4, LTBP1, BMPR2 miR-214 CHRD, ACVR2A Table 5: The top 5 GO terms enriched by the pivotal miRNAs.
Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1
activity and cyclin D1 expression.
Furthermore, genes potentially relevant to the pathogenesis of DN were confirmed experimentally, including the cytoskeletal regulator p21-activated kinase 1 (PAK1
) and superoxide dismutases (SOD1/SOD2) that catalyse ROS, which accumulates in response to hyperglycemia .