PAI-1


Also found in: Acronyms.

PAI-1

SERPINE1

A gene on chromosome 7q21.3-q22 that encodes a serine protease inhibitor that acts on tissue plasminogen activator (tPA) and urokinase, inhibiting fibrinolysis.

Molecular pathology
SERPINE1 mutations cause plasminogen activator inhibitor-1 deficiency; high concentrations of the gene product are associated with thrombophilia.

PAI-1

Abbreviation for plasminogen activator inhibitor-1.
References in periodicals archive ?
The human PAI-1 gene is located in the chromosome 7q22, and 180 polymorphic sites have been described within the PAI-1 gene (6, 12).
The mRNA level for KLF-4 or PAI-1 was normalized to internal control [beta]-actin and presented as the fold change over control with the [DELTA][DELTA]Ct method [30].
Fibrinogen and PAI-1 levels were higher in both the groups compared to the healthy subjects (p less than 0.
El PAI-1 reacciona con ambos u-PA y t-PA, pero con mayor especificidad para el t-PA.
As mentioned above, tPA and PAI-1 expression has been observed in skeletal muscle of humans (9) and animals (15,22).
TaqMan PCR analyses for PAI-1 and tPA were performed using predeveloped and commercially available primers and probe sets (cat.
The aliquots were removed after 24 h incubation and were frozen immediately at -80[degrees]C for later measurement of t-PA and PAI-1 (see below).
Of women with high concentrations of uPA and PAI-1 who got chemotherapy, about 12 percent relapsed, Prechtl reports.
He presented data from a new European multicenter trial in which uPA and PAI-1 levels were used to guide adjuvant chemotherapy in 556 women with node-negative breast cancer.
It also measured levels of plasminogen activator inhibitor, PAI-1, which dissolves TPA, acting as a balance against too much of the anti-clotting enzyme.