PCSK6

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PCSK6

A gene on chromosome 15q26.3 that encodes a broadly active endoprotease of the peptidase S8 family involved in the constitutive secretory pathway in both neuroendocrine and non-neuroendocrine tissues. It cleaves the RX(K/R)R consensus motif. Each PACE4/PCSK6 isoform (PACE4A-I, PACE4A-II, PACE4B, PACE4C, PACE4D, PACE4E-I and PACE4E-II) has a unique restricted distribution.
References in periodicals archive ?
Protein convertases, notably furin and PACE4, have been shown to play a role in tumor progression (61).
The proprotein convertases furin and PACE4 play a significant role in tumor progression.
We used LoVo cells (human colon carcinoma) to examine the expression of the genes for four widely-expressed SPCs (furin, PACE4, PC5, and PC7) in response to conditions of heat shock (42[degrees]C), hypoxia (1% oxygen), and both heat and hypoxia.
Partial Purification and Characterization of Secreted Proprotein Convertase Furin and PACE4.
Furin and PACE4 are widely expressed members of SPC family.
We examined the expression of the genes for four SPCs (furin, PACE4, PC5, and PC7) under stress conditions.
However, specific roles for PACE4 in these processes have been difficult to determine, in part because of overlapping substrate specificities and activities of the SPCs.
Substrate Specificity of the Mammalian Endoprotease PACE4.
RT-PCR analyses included sequence-specific SPC primer sets (PC1, PC2, PC4, PC5A, PC5B, PC7, Pskn9, PACE4, and furin) and the constitutively expressed gene for GAPDH (used as an internal standard for semi-quantitative analysis).
Four SPCs (futin, PACE4, PC5, and PC7) are widely expressed and play critical roles in development, homeostasis; and pathology.
While closely related to furin, the most well characterized member of this family, PACE4 has a restricted substrate range compared to furin, as PACE4 can process some, but not all, of the proproteins furin can process.