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Upregulated mRNAs Downregulated mRNAs Gene symbol Log2FC Gene symbol Log2FC EPB41L2 8.87 SIPA1L2 -7.60 SH3BP2 7.55 KMT2E -5.52 atm 7.42 PAAF1 -5.69 BTBD18 6.74 ARMC10 -5.07 PRRC2C 6.65 RTN4 -4.96 LPP 6.21 MAP3K3 -4.83 CEP192 6.20 MEF2A -4.81 ncstn 6.00 DIP2A -4.77 PDZD2 5.49 SLC5A3 -4.74 PRKCSH 5.44 POC5 -4.68
Receptor ADRM1 signaling also triggers the metastasis-associated protein PSMD12 through the proteins PSMD8 and PAAF1 and epigenetic regulation in stage 4 bladder cancer cells.
The design of a multiple drug combination for treating stage 1 bladder cancer depends on a strategy of inhibiting the highly expressed genes ADRM1, COPS5, PSMD8, SUMO2, CALR, PDIA3, DNAJB11, HSPA5, RPN1, CUL1, HSP90B1, KPNA2, PSMD12, ECT2, TK1, TUBA1C, HN1, and ENO1; activating the suppressed genes UBC, JUN, RARRES3, and FOS; and suppressing the drug's effect on the nondifferentially expressed genes BAG6, HUWE1, PAAF1, PSMD10, FAF2, PCYT1A, and PSMD10.
The bold proteins, including RARRES3, TUBA1C, PSMD8, HSPA1B, RPS20, CALR, PAAF1, and KPNA2, were the identified core network biomarkers.
The bold proteins RARRES3, TUBA1C, PSMD8, HSPA1B, RPS20, CALR, PAAF1, and KPNA2 were the identified core network biomarkers.