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A gene on chromosome 11q13 that encodes a protein that binds to NFKB1 or NFKB2 to form the NFKB complex (the most abundant form is NFKB1/RELA), which is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB); NFKBIA or NFKBIB inactivate the NFKB complex by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB)
marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex.
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Carisoprodol & meprobamate
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
In the camera department, the MediaTek Helio P65 enables dual camera systems up to 16MP+16MP with flexibility for wide/tele lenses.
Despite translocation, phosphorylation of the right p65 amino acid residues, and accessibility to a kappa-B equipped gene promotor, transcription by p65-p50 of the kappa-B TATA-less promoter also depends on the activation by phosphorylation of other nuclear transcription factors such as Sp1 [94, 95] and cAMP response element binding protein (CREB) [96].
The FFA level was significantly and negatively correlated with TLR9 mRNA expression level (P < 0.05) and significantly and positively correlated with TNF-[alpha] (P < 0.05); KLF4 was significantly and positively correlated with TLR9 (P < 0.05) and was negatively correlated to the subunit P65 of NF-[kappa]B (Figure 2(b)).
The protein of p65 and the ratio of p-p65/p65 was significantly higher in 10 [micro]g/mL FAC-treated group than that in the control group.
Sections were incubated with rabbit monoclonal antibodies against phosphorylated p65 (p-P65) (1: 100) (CST, #3033) and Nrf2 (1: 100) (Proteintech, 16396-1-AP) or mouse monoclonal antibody against cardiac troponin T (1: 100) (ABCAM, ab8295) for overnight.
After blocking with 1% bovine serum albumin (BSA) in Tris-buffered saline (TBS) containing Tween-20, the membranes were incubated with anti-human NF-[kappa]B p65 (diluted 1: 3000), anti-cyclin D1 (diluted 1: 3000), anti-p16 (diluted 1: 3000), and anti-cleaved caspase-3 (diluted 1: 3000) antibodies overnight.
The primary antibodies p-p38, p38, p-ERK1/2, ERK1/2, NFkB p65, and horseradish peroxidase-conjugated anti-rabbit secondary antibodies were from Cell Signaling Technology (Danvers, MA).
miR-9 directly targeted NF-[kappa]B mRNA and suppressed expression of both p65 and p50 subunits of NF-[kappa]B in ES-2 cells (19).
Objective: To study the relationship between TLR4 and NF-B p65 protein expressions in tumor tissues after radiotherapy and clinical radiosensitivity of patients with esophageal squamous cell carcinoma.