Rela(redirected from P65)
Also found in: Acronyms.
RELAA gene on chromosome 11q13 that encodes a protein that binds to NFKB1 or NFKB2 to form the NFKB complex (the most abundant form is NFKB1/RELA), which is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB); NFKBIA or NFKBIB inactivate the NFKB complex by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB)
marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex.