P5CDh | definition of P5CDh by Medical dictionary
ALDH4A1 (redirected from P5CDh)
ALDH4A1 A gene on chromosome 1p36 that encodes mitochondrial matrix NAD-dependent dehydrogenase (of the aldehyde dehydrogenase family of proteins), which catalyses the second step of the proline degradation pathway by converting pyrroline-5-carboxylate to glutamate, a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles.
ALDH4A1 mutation causes type-II hyperprolinaemia, which is characterised by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline.
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References in periodicals archive
In this study, one gene encoding pyrroline-5-carboxylate synthetase (P5CS), one gene encoding ornithine aminotransferase (OAT), one gene encoding pyrroline-5-carboxylate reductase (P5CR), one gene encoding proline dehydrogenase (ProDH), and one gene encoding pyrroline-5-carboxylate dehydrogenase (P5CDH
) related to proline metabolism were also identified (Figure 6(b) and Table S6).
In plants, the first report covered cis-NATs coding SRO5 and P5CDH, involved in the regulation of salt tolerance through RNAi pathway in Arabidopsis thaliana .
 found that the D1-pyrroline-5-carboxylate dehydrogenase (P5CDH) antisense overlapping gene pair is a stress-related gene.
SR05 mRNA is complementary to P5CDH
protein is an important enzyme for proline breakdown) and they together generate a dsRNA which is acted upon by siRNA biogenesis pathway factors (DCL2, RDR6, SGS3, and NRPD1A) to produce 24nt-siRNA.