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NFKB1A gene on chromosome 4q24 that encodes a kappa light polypeptide of NF-kappaB (nuclear factor-kappaB), a rapidly acting primary transcription factor which is found in all cell types and involved in cellular responses to stimuli, including cytokines and stress. NF-kappaB plays a key role in regulating the immune response to infection; it is involved in various biological processes including inflammation, immunity, differentiation, cell growth, tumourigenesis and apoptosis.
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P50The O2 tension at which Hb is1⁄2 (50%) saturated, a value equal to 26 torr–mm Hg in normal RBCs; the P50 value is obtained from the midpoint of the O2 dissociation curve–O2DC, and does not reflect the shape of the curve; with ↑ O2 affinity, P50 ↓, resulting in a 'left shift' of O2; ↑ P50 indicates ↓ O2 affinity for Hb. See Oxygen dissociation curve.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.