AKAP13

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AKAP13

A gene on chromosome 15q24-q25 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunits (RI/RII) of cAMP-dependent protein kinase A (PKA), confining PKA to discrete locations within the cell based on different targeting motifs. Alternative splicing of AKAP13 results in at least 3 transcript variants that encode different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain with various functions. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP-binding proteins, activating GTPase and resulting in signal transduction. The isoforms function as scaffolding proteins to co-ordinate a Rho-signalling pathway and function as PKA-anchoring proteins
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Lotto results for August 20, 2019 !-- -- (The Philippine Star) - August 21, 2019 - 12:00am EZ2/LVM (Evening draw) (In exact order) - 3 12 SUERTRES (Evening draw) (In exact order) - 3 7 0 6 digit - 0 8 9 4 1 0 6/42 Lotto - 19 16 15 7 8 23 P5,940,000.0 6/49 SuperLotto - 15 44 21 9 13 30 P47,427,732.00 6/58 UltraLotto - 12 47 9 6 20 35 P111,451,917.00
The MB also cut the RRR of the universal and commercial banks by a total of 2 percentage points, with about P95 billion released in May; about P47 billion in June; and another P47 billion in July.
Damage to property in Itbayat so far was pegged at P47 million.
Some P47.5 million worth of newly-purchased vital medical diagnostic and dialysis machines have been left unused or are not functioning in the provincial hospital of Camarines Norte, the Commission on Audit has revealed.
The seven grams confiscated from them were estimated to be worth P47,600 on the street.
There is no suggestion at this stage moving to the Principality, if it happens, CONTINUED ON P47
Margot said: "It was important to me that nothing felt like she was lying, and that she did everything with the best intentions." n See p47 for more on I, Tonya Saoirse Ronan for Lady Bird At just 23, this is Saoirse's third Oscar nomination (the Irish star got her first nod at 13 for Atonement).
P.Beatty III (P47): The Codex, Its Scribe, and Its Text
Two-way ANOVA comparisons were used to calculate differences in the OCT measurements at P19, P24, P32, and P47. Post hoc analysis was performed using Tukey's multiple comparisons for all pair-wise comparisons.
Speaking after a 2-1 win over Cardiff that kept the Blues in the hunt for a continental return next season, he said: Full story - P47 "It's mixed feelings because you can't say no to playing in Europe.
"We showed a lot of character and created loads of chances." MATCH REPORT - P47