CYP17A1

(redirected from P450c17)

CYP17A1

A gene on chromosome 10q24.3 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP17A1 localises to the endoplasmic reticulum and has 17 alpha-hydroxylase and 17, 20-lyase activities; it is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens and oestrogens.

Molecular pathology
CYP17A1 mutations are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17, 20-lyase deficiency, pseudohermaphroditism and adrenal hyperplasia.
References in periodicals archive ?
Some studies have focused on the ultrastructure and morphology of the different cell types present in each layer of the adrenal cortex and medulla during intrauterine development and the immunolocalization of steroidogenic enzymes, especially that responsible for androgens production, as cytochrome P450c17 in species of wild mammals (Quinn et al.
Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3-beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPAR gamma agonist activity.
The immune-histochemistry of animals heavily intoxicated has shown that the negative effects of Pb on the production of progesterone and testosterone were due mainly to the decrease in the expression of cytochrome P450c17 that catalyzes the hydroxylation of progesterone, and then its transformation into and rostenedione, the immediate precursor of testosterone [38].
In the adrenal cortex, this is processed into either glucocorticoids and androgens in zona fasciculate and zona reticularis (which contain the microsomal enzyme cytochrome P450c17[alpha]-hydroxylase: P450c17 and 17,20 lyase) or into mineralocorticoids in zona glomerulosa (which does not contain P450c17 and 17,20 lyase, but contains aldosterone synthase, CYP11B2).
At ovarian level it enhance P450c17 enzyme and lead to intraovarian hyperandrogenism that affect follicular growth
Tambien los ovarios poliquisticos, como fenomeno periferico, podrian ser el defecto primario a partir del cual puede llegarse al desarrollo del SOP, si sobre aquellos actuan determinados factores, tales como: la generacion anormal a nivel hipotalamico de los pulsos de GnRH, cambios del factor de crecimiento insulinotropico dependiente de hormona de crecimiento tipo 1 (GH-IGF-1), el incremento en la actividad de la enzima esteroidogenica P450c17, la obesidad y la resistencia a la insulina.
17OHD has an autosomal recessive heritage and cytochrome P450c17 enzyme gene locus is 10q24-q25.
Dysregulation of cytochrome p450c17, which is the main enzyme in both the adrenal glands and the ovaries for androgen synthesis, has been shown to be one mechanism of this disorder.
Cytochrome P450c17 has two enzyme activities, 17-alpha-hydroxylase and 17,20-lyase.
Overdeki insulin almaclarini etkileyerek P450c17 enziminini uyarir ve over kaynakli androjen sentezini arttirir.
Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome.
Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17.