CYP17A1

(redirected from P450c17)

CYP17A1

A gene on chromosome 10q24.3 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP17A1 localises to the endoplasmic reticulum and has 17 alpha-hydroxylase and 17, 20-lyase activities; it is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens and oestrogens.

Molecular pathology
CYP17A1 mutations are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17, 20-lyase deficiency, pseudohermaphroditism and adrenal hyperplasia.
References in periodicals archive ?
Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3-beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPAR gamma agonist activity.
The immune-histochemistry of animals heavily intoxicated has shown that the negative effects of Pb on the production of progesterone and testosterone were due mainly to the decrease in the expression of cytochrome P450c17 that catalyzes the hydroxylation of progesterone, and then its transformation into and rostenedione, the immediate precursor of testosterone [38].
17OHD has an autosomal recessive heritage and cytochrome P450c17 enzyme gene locus is 10q24-q25.
Cytochrome P450c17 has two enzyme activities, 17-alpha-hydroxylase and 17,20-lyase.
Overdeki insulin almaclarini etkileyerek P450c17 enziminini uyarir ve over kaynakli androjen sentezini arttirir.
Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17.
The molecular connection between insulin resistance and hyperandrogenism remained enigmatic until these 2 cardinal features of PCOS were elegantly unified by the discovery of a mutant serine kinase that hyperphosphorylates P450c17 and the insulin receptor [beta]-chain (3).
For example, exogenous estrogen treatment can also result in reduction of expression of several steroidogenic enzymes, including P450c17, 3[beta]HSD, and P45011[beta] in the differentiating testis (Govoroun et al.
65) Since serine phosphorylation of P450c17 (the key regulatory enzyme of androgen biosynthesis) increases enzyme activity leading to androgen biosynthesis, (66) it is possible that a single defect (serine phosphorylation) can produce both insulin resistance and hyperandrogenism in a subgroup of PCOS patients.
Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPAR gamma agonist activity.
Immunolocalization of steroidogenic enzymes p450scc, 3-beta-hsd, p450c17 and p450arom in the corpus-luteum of the Hokkaido brown bear (Ursus arctos Yesoensis) in relation to delayed implantation.
Physiology and molecular biology of P450c21 and P450c17.