cytochrome P450

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CYP11A1

A gene on chromosome 15q23-q24 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP11A1 localises to the mitochondrial inner membrane and catalyses the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones.

cytochrome P450

Abbreviation: CYP
A group of enzymes present in every type of cell in the body except red blood cells and skeletal muscle cells. They are important in metabolizing substances normally present in the body such as steroids, fat-soluble vitamins, fatty acids, prostaglandins, and alkaloids. The P450 enzymes also detoxify drugs and a great number of environmental pollutants, such as carcinogens present in tobacco smoke and charcoal-broiled meat, polychlorinated biphenyls, and dioxin. Specialized types of cytochrome P450 are involved in the synthesis of nitric oxide.
See also: cytochrome

cytochrome P450

A family of enzymes responsible for the detoxification and elimination of foreign substances including many drugs by hydroxylation and increasing their solubility. The group has been intensively studied because mutations of the cytochrome P450 gene have been found to be associated with a number of diseases including Addison's disease, liver cancer and Parkinson's disease. Cytochrome P450 can also interfere with drug treatment. Selective inhibitors of aromatase-specific cytochrome P450 have been developed to assist in the treatment of breast cancer.

cytochrome P450

hepatic microsome responsible for biotransformation of local anaesthetic agents into simpler chemical compounds
References in periodicals archive ?
But Joselito Tura only got P450,000 from the government, less than half of the promised reward money.
Cytochrome P450 (P450) enzymes are responsible for the metabolism of a large number of drugs in the liver and gastrointestinal tract.
Most of the metabolic pathways leading to their biosynthesis and catabolism are now well characterized, and all but one involve oxygenases belonging to the family of cytochrome P450 (P450) oxygenases.
The tobacco smoke contained N-nitrosamines that are metabolised to genotoxic products by different P450 enzymes particularly P450 2E1 and 2A6 [6].
Initial Registration Fee of P600 and Annual Registration Fee of P450 for 2015-2018 for MECHANICAL ENGINEER;
Host plant species can passively affect the biochemistry of arthropods and one of the most important effects is on the detoxification enzymes involved in insecticide metabolism, including general esterases, glutathione S-transferases, and cytochrome P450 monooxygenases (e.
Cytochrome P450 2J2 (CYP2J2) is the exclusive member of the human 2J subfamily [15].
CYP2D6 is one of the genes in the cytochrome P450 family of enzymes that is responsible for metabolising 25% of all prescribed therapeutics.
3-1) Steroid hydroxylations and the participation of hemoprotein cytochrome P450.
com)-- AAXA Technologies, a leader in Pico and Micro projectors announces the release of the AAXA P450 - a 450 lumen High-Definition (HD) pico projector based on AAXA's popular P300 platform.
Studying the ways in which the cytochrome P450 family of enzymes processes valproic acid, the Johns Hopkins biochemists found that it can activate the protein AMPK, which was already known to be a good drug target for treating metabolic disorders like type 2 diabetes and obesity, Daily Science reported.
The new work reveals that two members of the P450 gene superfamily in particular are highly expressed in resistant Tiassale mosquitoes: CYP6M2 and CYP6P3.