MAPK1

(redirected from P42 MAP kinase)

MAPK1

A gene on chromosome 22q11.2|22q11.21 that encodes a protein of the MAP kinase family. MAP kinases (e.g., extracellular signal-regulated kinases) integrate multiple biochemical signals, and are involved in cell proliferation, differentiation, transcription, regulation and development. Once MAPK1 is activated by phosphorylation by an upstream kinase, it translocates to the nucleus of the stimulated cell, where it phosphorylates target molecules.
References in periodicals archive ?
The histograms show the fold increase in levels of phosphop44/ p42 MAP kinase in each cell versus those of unstimulated cells.
28) found that p42 MAP kinase activation regulates the normal progression through the cell cycle and is an essential component of the spindle assembly checkpoint.