MAPK11

(redirected from P38B)

MAPK11

A gene on chromosome 22q13.33 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK11 is preferentially activated by MAPK kinase—especially MKK6; it is closely related to p38 MAP kinase and both are activated by pro-inflammatory cytokines and environmental stress.
References in periodicals archive ?
The mitogen-activated protein kinase (MAPK) is one of revolutionary signaling pathways in mammalian cells including the extracellular signal-regulated kinases (ERK1/2), the p38 MAP kinases (p38a, p38b, p38g, and p38d), the c-Jun-NH2-terminal kinases (JNK1, JNK2, and JNK3) and ERK5 [27].
O'Keefe et al., "The three-dimensional structure of MAP kinase p38B: different features of the ATP-binding site in p38B compared with p38[alpha]," Acta Crystallographica D, vol.
We hypothesized that p38B MAPK directly phosphorylates CBP, leading to its potentiation.