Zhang et al., "Protein interacting C-kinase 1 modulates surface expression of P2Y6
purinoreceptor, actin polymerization and phagocytosis in microglia," Neurochemical Research, vol.
There are eight subtypes of P2Y receptors (P2Y1, P2Y2, P2Y4, P2Y6
, P2Y11, P2Y12, P2Y13, and P2Y14), which are ubiquitously expressed in body, including the CNS .
Central role of P2Y6
UDP receptor in arteriolar myogenic tone.
(2007) UDP acting at P2Y6
receptors is a mediator of microglial phagocytosis.
Jacobson, "Attenuation of apoptosis in vitro and ischemia/ reperfusion injury in vivo in mouse skeletal muscle by P2Y6
receptor activation," Pharmacological Research, vol.
The first evidence relating purinergic receptor and fibrosis showed the presence of functional P2Y2, P2Y4, and P2Y6
receptors in both quiescent and activated HSCs .
There are seven known P2X receptor subtypes (P2X1-7) and eight P2Y receptor subtypes (P2Y1, P2Y2, p2y4, P2Y6
, P2Y11, P2Y12, P2Y13, and P2Y14) .
receptor-mediated proinflammatory signaling in human bronchial epithelia," PLoS One, vol.
Indeed, these receptors are phylogenetically related to purinergic P2Y class of GPCRs  and evidence reported in the literature suggests the existence of additional receptors responding to CysLTs , such as GPR17 , GPR99 , PPARy , P2Y6
, and P2Y12 .
Neutrophil defensins have been found to augment the expression of IL-8 in the airway epithelial cells through the P2Y6
receptor.50) Niyonsaba et al.
Nasu-Tada et al., "UDP acting at P2Y6
receptors is a mediator of microglial phagocytosis," Nature, vol.
We proposed the involvement of the purinergic P2Y6
receptor in this mechanism based on a strong reduction of MSU crystal-induced NET release by general purinergic receptor inhibitors and the P2Y6-specific inhibitor MRS2578 .