P2RY2

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P2RY2

A gene on chromosome 11q13.5-q14.1 that encodes a subfamily of G protein-coupled receptors, which acts as a receptor for adenosine and uridine nucleotides and may participate in controlling the cell cycle of endometrial carcinoma cells.
References in periodicals archive ?
ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors.
The first evidence relating purinergic receptor and fibrosis showed the presence of functional P2Y2, P2Y4, and P2Y6 receptors in both quiescent and activated HSCs [130].
2008), demonstrated that P2Y2 and P2Y11 receptors were expressed in near-IR light irradiated normal human neural progenitor cells in vitro (33).
Extracellular nucleotides block bone mineralization in vitro: Evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate.
Long-term exposure to LPS enhances the rate of stimulated exocytosis and surfactant secretion in alveolar type II cells and upregulates P2Y2 receptor expression.
Diquafosol tetrasodium is a new dinucleotide which functions as an agonist at the P2Y2 receptor and has been developed for the treatment of dry eye in humans.
Inspire's CEO, added, "The activation of P2Y2 receptors in the back of the eye to remove pathological fluid is an approach that could potentially provide benefit for patients with RRD, as well as for patients with other sight-threatening diseases that involve fluid accumulation in or around the retina.
INHIBITION OF P2Y2 RECEPTOR DESENSITIZATIONBY INHIBITION OF PROTEIN KINASE C ACTIVITY.
Transient up-regulation of P2Y2 nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes.