P2RY1

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P2RY1

A gene on chromosome 3q25.2 that encodes a G protein-coupled receptor that acts as a receptor for extracellular ATP and ADP. In platelets, P2RY1 binding to ADP leads to mobilisation of intracellular calcium ions by activating phospholipase C, a change in platelet shape and platelet aggregation.
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Structures of human P2Y1 receptor bring new excitement to GPCR research
COX -1 enzyme gene, P2Y1 and P2Y12 platelet receptor genes and glycoprotein (GP) IIb/IIIa genes are most studied genes in aspirin resistance, but there are conflicting results regarding association of aspirin non-response and gene polymorphism (19-21).
The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel.
13) ADP interacts with two G-protein-coupled platelet purinergic receptors, P2Y1 and P2Y12.
This demonstrated that in some individuals Glucosamine with Celadrin will decrease platelet response to collagen and arachidonic acid (mimicking aspirin-like effects) as well as affecting ADP P2Y1 receptors, but not P2Y12 receptors.
The effect of ADP on platelets is mediated by two P2Y receptors, designated P2Y1 and P2Y12.
P2Y1 and P2Y2 receptors are coupled to the NO/cGMP pathway to vasodilate the rat arterial mesenteric bed.