P2RY1

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P2RY1

A gene on chromosome 3q25.2 that encodes a G protein-coupled receptor that acts as a receptor for extracellular ATP and ADP. In platelets, P2RY1 binding to ADP leads to mobilisation of intracellular calcium ions by activating phospholipase C, a change in platelet shape and platelet aggregation.
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35]S]dATPaS interaction with P2Y1 purinoceptor in rat brain membranes.
Estos nucleotidos ejercen sus funciones a traves de tres purinoceptores P2 en plaquetas: P2X1 (receptor ionotropico que provoca una rapida entrada de calcio hacia el citosol), P2Y1 (receptor metabotropico que moviliza el calcio desde las cisternas internas) y P2Y12 (receptor acoplado a la proteina Gai que estabiliza la agregacion plaquetaria) (39-41).
Central role for hydrogen peroxide in P2Y1 ADP receptor-mediated cellular responses in vascular endothelium.
COX -1 enzyme gene, P2Y1 and P2Y12 platelet receptor genes and glycoprotein (GP) IIb/IIIa genes are most studied genes in aspirin resistance, but there are conflicting results regarding association of aspirin non-response and gene polymorphism (19-21).
The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel.
13) ADP interacts with two G-protein-coupled platelet purinergic receptors, P2Y1 and P2Y12.
This demonstrated that in some individuals Glucosamine with Celadrin will decrease platelet response to collagen and arachidonic acid (mimicking aspirin-like effects) as well as affecting ADP P2Y1 receptors, but not P2Y12 receptors.
P2Y1 and P2Y2 receptors are coupled to the NO/cGMP pathway to vasodilate the rat arterial mesenteric bed.