Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1
HEK-293 cells are known to abundantly express a diverse repertoire of receptors such as [beta]2-adrenergic, muscarinic acetylcholine, sphingosine-1-phosphate, P2Y1
and P2Y2, corticotropin-releasing factor type 1, and somatostatin- and thyrotropin-releasing hormone receptors, and citalopram has been shown to interact strongly with some of these receptors, in the concentration range used in this study, so it may well be eliciting epigenetic effects through these pathways.
There are eight subtypes of P2Y receptors (P2Y1
, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14), which are ubiquitously expressed in body, including the CNS .
Kinetics of [[.sup.35]S]dATPaS interaction with P2Y1
purinoceptor in rat brain membranes.
Experimental evidence demonstrated that EA could relieve visceral hyperalgesia in rats with visceral pain by reducing the expression of P2X2 and P2X3 receptors in the colon and spinal cord  and P2Y1
receptors in DRG cells.
Samani, "Dimorphism in the P2Y1
ADP receptor gene is associated with increased platelet activation response to ADP," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Cunha, "Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1
, P2Y2, and/or P2Y4 receptors in the rat hippocampus," The Journal of Neuroscience, vol.
Ciccarelli et al., "P2Y1
and cysteinyl leukotriene receptors mediate purine and cysteinyl leukotriene co-release in primary cultures of rat microglia," International Journal of Immunopathology and Pharmacology, vol.
McCaig, "Physiological electrical signals promote chain migration of neuroblasts by up-regulating P2Y1
purinergic receptors and enhancing cell adhesion," Stem Cell Reviews and Reports, vol.
It was shown that clopidogrel (a P2Y1
, 2 ADP receptor blocker) significantly reduced the incidence of CAA .
PGE1 is used as a suppressor of intracellular free calcium to reduce the nonspecific contribution of ADP binding to P2Y1
Estos nucleotidos ejercen sus funciones a traves de tres purinoceptores P2 en plaquetas: P2X1 (receptor ionotropico que provoca una rapida entrada de calcio hacia el citosol), P2Y1
(receptor metabotropico que moviliza el calcio desde las cisternas internas) y P2Y12 (receptor acoplado a la proteina Gai que estabiliza la agregacion plaquetaria) (39-41).