P2RY12

(redirected from P2Y)

P2RY12

A gene on chromosome 3q24-q25 that encodes a G protein-coupled receptor for various drugs as well adenosine and uridine nucleotides.
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The ATP released through Panx1 channels contributes, in great part, to the a1-adrenoceptor-mediated vasoconstriction through the activation of P2Y receptors.
A review of the current state of pannexin channels as they relate to the blood vessel wall
2001) Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors.
Purinergic signaling in microglia in the pathogenesis of neuropathic pain
Alem da influencia vascular, a vasodilatacao tambem tem uma interferencia neural, mediada pela acao do ATP, atraves dos receptores purinergicos P2Y e P2X.
RESPOSTAS CARDIOVASCULARES AO ESFORCO MAXIMO: EFEITOS VASODILATADORES E HIPOTENSORES/Cardiovascular responses to maximal effort: vasodilator and hypotensive effects
1), which are broadly expressed on immune and other cells, are members of the P2 class of receptors for extracellular nucleotides and are classified into two families, P2Y and P2X (Burnstock and Boeynaems, 2014).
Imaging adenosine triphosphate (ATP)
In the setting of percutaneous coronary intervention with a bare metal or drug-eluting stent for patients with either non-ST-elevation ACS or ST-elevation MI, the AHA/ACC guidelines give a class I recommendation for at least 12 months of dual-antiplatelet therapy (DAPT) with aspirin and a P2Y inhibitor.
Most cardiologist's misstep on aspirin in ACS
Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: an experimental study.
Pistacia integerrima ameliorates airway inflammation by attenuation of TNF-[alpha], IL-4, and IL-5 expression levels, and pulmonary edema by elevation of AQP1 and AQP5 expression levels in mouse model of ovalbumin-induced allergic asthma
He HY, Zheng J, Li Y, Heng WJ, Fang WG (2005) SHP2 and MKP5 in P2Y purinergic receptor-mediated prostate cancer invasion.
Study of molecular mechanisms of PDLIM4/RIL in promotion of the development of breast cancer
Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone inhibits expression of P2Y receptors in cystic fibrosis tracheal gland cells.
Immunization with 3-oxododecanoyl-L-homoserine lactone-r-PcrV conjugate enhances survival of mice against lethal burn infections caused by Pseudomonas aeruginosa
11 Although insulin suppresses P2Y mediated platelet aggregation in healthy subjects12 it is known that if there is insulin resistance such as DM accompanying central obesity obesity and HT there is unresponsiveness to the antiaggregant effect of insulin.
Acetylsalicylic acid resistance in patients with Type 2 diabetes mellitus prediabetes and non-diabetic coronary artery disease
Substances known to specifically block the platelet's P2Y 12 receptor include the thienopyridine class of drugs, including clopidogrel, prasugrel, ticagrelor, and ticlopidine.
Laboratory measurement of platelet reactivity: consider the impact of new drugs, generic options and healthcare economics
Effects of Elevated Fibrinogen, Factor VIII, and von Willebrand factor on the INNOVANCE[R] PFA P2Y cartridge
ASCLS Annual Meeting 2011: official abstracts of submitted papers, case studies and posters
Key classes of mechanism of action include endothelin receptor antagonists, platelet aggregation inhibitors, phosphodiesterase inhibitors, serotonin pathway antagonists, angiotensin receptor antagonists, P2Y 12 receptor inhibitors, PDE5 inhibitors, prostacyclin (PGI2) agonists, nitric oxide synthetase inhibitors.
Pulmonary Arterial Hypertension (PAH) - Pipeline Assessment and Market Forecasts to 2016 Now Available at ReportsandReports

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