P2RY12

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P2RY12

A gene on chromosome 3q24-q25 that encodes a G protein-coupled receptor for various drugs as well adenosine and uridine nucleotides.

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P2Y12

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This increase in ATP levels has been suggested to play a role in the chemotaxis and activation of inflammatory cells, such as neutrophils, through P2Y receptors [48, 49].

Inflammation and immune response in COPD: where do we stand?

Extracellular ATP acts as a paracrine messenger in these waves, since it activates purinergic receptors (P2X and P2Y) in astrocytes of surrounding cells, thus resulting in an increase of [[[Ca.sup.2+]].sub.i] [143].

Possible involvement of TLRs and hemichannels in stress-induced CNS dysfunction via mastocytes, and glia activation

Since its establishment, VP-46 has flown seven aircraft variants; the PM-2, P2Y, PBY Catalina, PBM-3 Mariner, P5M Marlin, P-2 Neptune, and since Jan.

Maritime Patrol (VP) Squadron 46 "Grey Knights"

The interpersonal distances were obtained with the equation D = [square root of ([(P2x - P1x).sup.2] + [(P2y - P1y).sup.2])], where "D" refers to the distance between players (P1 and P2).

Effects of Spatiotemporal Constraints and Age on the Interactions of Soccer Players when Competing for Ball Possession

Currently, both ionotropic P2X receptors and metabotropic P2Y receptors have been identified as key receptors in mediating neuropathic pain [49].

Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines

The ATP released through Panx1 channels contributes, in great part, to the a1-adrenoceptor-mediated vasoconstriction through the activation of P2Y receptors.[16],[17],[27 Interestingly, this complementary vasoconstrictor mechanism is only coupled to a1-adrenoceptor activation while the response to serotonin or endothelin-1 is not affected by typical Panx1 channel blockers such as the Panx1 mimetic peptide [10] Panx and probenecid, which was confirmed in the SMC Panx1-deficient mice.[16] This observation has now been confirmed independently pharmacologically [28] and genetically [29] in mouse mesenteric arterioles (as well as humans [data not shown]) highlighting the importance of the Panx1-a1-adrenerigc interaction, especially for translational outcomes.{Figure 1}

A review of the current state of pannexin channels as they relate to the blood vessel wall

(2001) Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors.

Purinergic signaling in microglia in the pathogenesis of neuropathic pain

Alem da influencia vascular, a vasodilatacao tambem tem uma interferencia neural, mediada pela acao do ATP, atraves dos receptores purinergicos P2Y e P2X.

RESPOSTAS CARDIOVASCULARES AO ESFORCO MAXIMO: EFEITOS VASODILATADORES E HIPOTENSORES/Cardiovascular responses to maximal effort: vasodilator and hypotensive effects

P2 receptors are classified into several subtypes of ligand-gated ion channels (P2X1-P2X7 subunits) and eight distinct G protein-coupled receptors (P2Y) which are both characterized by a variety of distinct properties and a broad range of ATP sensitivities ranging from nanomolar (P2Y receptor) to tenth micromolar (P2X) or millimolar for P2X7 [1, 11-14].

Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors

The role and transduction mechanisms of P2Y receptors," Cellular Signalling, vol.

Sterile Neuroinflammation and Strategies for Therapeutic Intervention

There was a concomitant upregulation of the P2Y purinoreceptor in the presence of the EF, and interestingly, blocking the receptor using drugs or siRNA resulted in a loss of directedness in NPCS [54].

Environmental Factors That Influence Stem Cell Migration: An "Electric Field"

Interestingly, ADAM17 can also be activated by mitochondrial ROS in a src- and PKC-independent way via the activation of the P2Y receptor by ATP in fibroblast [128] and FAS-mediated apoptosis in neutrophils [129].