P2RY12

P2RY12

A gene on chromosome 3q24-q25 that encodes a G protein-coupled receptor for various drugs as well adenosine and uridine nucleotides.
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P2RY1 and P2RY12 polymorphisms and on-aspirin platelet reactivity in patients with coronary artery disease.
Among the dysregulated genes, the top 12 genes from All Sources, Blood Source, Lymphocyte Source, and Monocyte Source were CDC37, NCOA2, P2RY12, RXRB, EDEM2, ACTN4, STX12, PPM1A, PRKACB, DUSP10, VEGFA, and SLC44A2.
These molecular signatures include Sall1, Tgfbr1, P2ry12, Fcrls, and Gpr34 genes that are dependent on the transforming growth factor-[beta] (TGF[beta]) signaling--an essential pathway required for the development of microglia [16].
Associations between P2RY12 gene polymorphisms and risks of clopidogrel resistance and adverse cardiovascular events after PCI in patients with acute coronary syndrome.
[4] Human genes: APOE, apolipoprotein E; SLCO1B1, solute carrier organic anion transporter family member 1B1; LPA, lipoprotein(a); SORTI, sortilin 1; ABCB1, ATP binding cassette subfamily B member 1; ABCG2, ATP binding cassette subfamily G member 2; HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase; CELSR2, cadherin EGF LAG sevenpass G-type receptor 2; PSRC1, proline and serine rich coiled-coil 1; KIF6, kinesin family member 6; CYP2C19, cytochrome P450 family 2 subfamily C member 19; P2RY12, purinergic receptor; CYP2C9, cytochrome P450 family 2 subfamily C member 9; CES1, carboxylesterase 1; UGT2B7, UDP glucuronosyltransferase family 2 member B7; VKORC1, vitamin K epoxide reductase complex subunit 1.
El efecto del clopidogrel puede ser evaluado midiendo la agregacion plaquetaria inducida por ADP o por el analisis de fosforilizacion mediada por P2RY12 por citometria de flujo.