Among the dysregulated genes, the top 12 genes from All Sources, Blood Source, Lymphocyte Source, and Monocyte Source were CDC37, NCOA2, P2RY12
, RXRB, EDEM2, ACTN4, STX12, PPM1A, PRKACB, DUSP10, VEGFA, and SLC44A2.
These molecular signatures include Sall1, Tgfbr1, P2ry12
, Fcrls, and Gpr34 genes that are dependent on the transforming growth factor-[beta] (TGF[beta]) signaling--an essential pathway required for the development of microglia .
Associations between P2RY12
gene polymorphisms and risks of clopidogrel resistance and adverse cardiovascular events after PCI in patients with acute coronary syndrome.
 Human genes: APOE, apolipoprotein E; SLCO1B1, solute carrier organic anion transporter family member 1B1; LPA, lipoprotein(a); SORTI, sortilin 1; ABCB1, ATP binding cassette subfamily B member 1; ABCG2, ATP binding cassette subfamily G member 2; HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase; CELSR2, cadherin EGF LAG sevenpass G-type receptor 2; PSRC1, proline and serine rich coiled-coil 1; KIF6, kinesin family member 6; CYP2C19, cytochrome P450 family 2 subfamily C member 19; P2RY12
, purinergic receptor; CYP2C9, cytochrome P450 family 2 subfamily C member 9; CES1, carboxylesterase 1; UGT2B7, UDP glucuronosyltransferase family 2 member B7; VKORC1, vitamin K epoxide reductase complex subunit 1.