P2RY12

P2RY12

A gene on chromosome 3q24-q25 that encodes a G protein-coupled receptor for various drugs as well adenosine and uridine nucleotides.
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Associations between P2RY12 gene polymorphisms and risks of clopidogrel resistance and adverse cardiovascular events after PCI in patients with acute coronary syndrome.
4] Human genes: APOE, apolipoprotein E; SLCO1B1, solute carrier organic anion transporter family member 1B1; LPA, lipoprotein(a); SORTI, sortilin 1; ABCB1, ATP binding cassette subfamily B member 1; ABCG2, ATP binding cassette subfamily G member 2; HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase; CELSR2, cadherin EGF LAG sevenpass G-type receptor 2; PSRC1, proline and serine rich coiled-coil 1; KIF6, kinesin family member 6; CYP2C19, cytochrome P450 family 2 subfamily C member 19; P2RY12, purinergic receptor; CYP2C9, cytochrome P450 family 2 subfamily C member 9; CES1, carboxylesterase 1; UGT2B7, UDP glucuronosyltransferase family 2 member B7; VKORC1, vitamin K epoxide reductase complex subunit 1.
El efecto del clopidogrel puede ser evaluado midiendo la agregacion plaquetaria inducida por ADP o por el analisis de fosforilizacion mediada por P2RY12 por citometria de flujo.