ARID1A

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ARID1A

A gene on chromosome 1p36.1-p35 that encodes AT-rich interactive domain-containing protein 1, which is highly expressed in the spleen, thymus, prostate, testes, ovaries, small intestine, colon and peripheral leukocytes. ARID1A is involved in transcriptional activation and repression of select genes by chromatin remodelling (by altering DNA-nucleosome topology). It is also involved in vitamin D-coupled transcription regulation by associating with the WINAC complex, a chromatin-remodelling complex recruited by vitamin D receptor.

ARID1A belongs to the neural progenitors-specific chromatin remodelling (npBAF) and the neuron-specific chromatin remodelling (nBAF) complexes, which are involved in switching developing neurons from stem/progenitors to post-mitotic chromatin remodelling as they exit the cell cycle and become committed to their adult state.

Molecular pathology
Defects in ARID1A cause mental retardation autosomal dominant type 14.
References in periodicals archive ?
The Davao City Investment Promotion Center here said the city saw the increase in the number of businesses as signficant, now reaching 40,000, with total aggregate capitalization of P270 billion.
8 percent above its target of P22 million); Port of Iloilo - P270 million (7.
In the market, a black rhino costs about P350 000 to P400 000, while a white rhino can cost between P270 000 and P320 000,'he disclosed.
00 in Tabuk City, Bangued, Bontoc, Lagawe, Banaue, Bugiuas, Bauko, Sagada and Tublay, and P270.
Manila: A 46-year-old housewife from Metro Manila's Las Pinas placed a bet on the ATM number of her husband and hit the P270 million (Dh22.
These belong respectively to the 27-metre and 90-tonne P270 and 35-metre and 140-tonne P350 models of aluminium craft, which in different versions have been sold to national and Mediterranean customers, including Libya, Croatia, Slovenia, Tunisia and Romania.
stainless steel, 10 |xm, Waters); preparative HPLC was performed on a Elite P270 preparative HPLC system equipped Preparative [C.
As diferencas de manejos entre os rebanhos foram significativas (P<0,05) sobre os pesos estimados, com excecao do P180 e do P270.
The P270 is the first device on the market that combines UMA and 3G network technology.
Argonne and Maxwell have agreed on an active parallel system configuration that will combine a standard lithium-ion plug-in hybrid battery with a string of 112 of Maxwell's BOOSTCAP BCAP0650 P270 650-farad ultracapacitor cells, along with appropriate power electronics and cooling and safety-related features.
The 2018 awards are valued at about APS4 million, or P270 million.
The decision also said that Juan, who went in critical condition after sustaining at least four gunshot wounds and who was hurt after a grenade explosion, was also awarded an additional P270,872.