ARID1A

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ARID1A

A gene on chromosome 1p36.1-p35 that encodes AT-rich interactive domain-containing protein 1, which is highly expressed in the spleen, thymus, prostate, testes, ovaries, small intestine, colon and peripheral leukocytes. ARID1A is involved in transcriptional activation and repression of select genes by chromatin remodelling (by altering DNA-nucleosome topology). It is also involved in vitamin D-coupled transcription regulation by associating with the WINAC complex, a chromatin-remodelling complex recruited by vitamin D receptor.

ARID1A belongs to the neural progenitors-specific chromatin remodelling (npBAF) and the neuron-specific chromatin remodelling (nBAF) complexes, which are involved in switching developing neurons from stem/progenitors to post-mitotic chromatin remodelling as they exit the cell cycle and become committed to their adult state.

Molecular pathology
Defects in ARID1A cause mental retardation autosomal dominant type 14.
References in periodicals archive ?
Every year, the smoking epidemic translates to roughly P270 billion in healthcare costs and productivity losses, equivalent to 1.9 percent of the country's GDP.
Cebu recently turned over a 35-HP tractor with implements worth P1,048,000 and two units of shredders worth P270,000 each to farmer-beneficiaries in Barili, Cebu.
During a good harvest, when the seas are calmer, prices drop as low as P270 to P300 per kilo, ' revealed Kalbi.
Ms Benifield noted that the city proposed over P270 million adding that the budget was made up of their own resources of revenue of P37.8 million and over P230 million as Revenue Grant from the Ministry of Local Government and Rural Development.
Apolinario said the group of Saurin was able to cart away some P270,000 worth of school items and cash.
"For April, net issuance of government securities amounting to P8.82 billion brought the increase in the level of domestic portfolio, while P270 million was trimmeddue to revaluation of onshore dollar bonds due to peso appreciation," the BTr said.
Manila: A 46-year-old housewife from Metro Manila's Las Pinas placed a bet on the ATM number of her husband and hit the P270 million (Dh22.5 million) grand prize of a government-run agency's numbers game, a senior official said.
O ano de nascimento foi significativo sobre PN, P30, P90 e P270, sugerindo a influencia indireta da estacionalidade na producao de alimentos sobre os pesos estudados.
The two phones, P250 and P270, will be released by Samsung in multiple countries in Europe.
Argonne and Maxwell have agreed on an active parallel system configuration that will combine a standard lithium-ion plug-in hybrid battery with a string of 112 of Maxwell's BOOSTCAP BCAP0650 P270 650-farad ultracapacitor cells, along with appropriate power electronics and cooling and safety-related features.
Between Kanota and Ogle, three (p1882, p270, and p1158) showed presence-or-absence polymorphisms between (Fig.
Ten people die every hour due to tobacco-related illnesses, while smoking costs the country economic and productivity losses of up to P270 million.