PRPF8

(redirected from P220)
Also found in: Acronyms.

PRPF8

A gene on chromosome 17p13.3 that encodes protein which is a central component of the spliceosome and thought to play a role in aligning pre-mRNA 5'- and 3'-exons for ligation. It interacts with U5 snRNP proteins SNRP116 and WDR57/SPF38, and with EFTUD2 and SNRNP200.

Molecular pathology
Defects in PRPF8 cause retinitis pigmentosa type 13.
References in periodicals archive ?
First, before we cover exactly what features make this a "Legion" pistol, let's look at the specs of this particular P220.
The P220 Hunter has an adjustable rear sight and SIG's TFO (tritium fiber optic) front sight.
The P220 operates by a locked-breech, short-recoil action harking back to John M.
The P220, made by the US-based Sigarms company, is the "weapon of choice" of elite units worldwide.
Lopez said he still has to look at the reports to see if, indeed, prices have gone up because during the latest National Price Coordinating Council meeting, cement prices hovered around P220 to P225 only depending on areas.
The regular price of pork meat in the market ranges from P220 to P230 per kilo.
It is said you can't teach an old dog new tricks, but thanks to SIG SAUER's Model P220 10mm Hunter, I have learned a valuable new "trick " with no pain and much gain.
The SIG P220 pistol was also available in this caliber and can be found from time to time at auctions.
I've carried a SIG SAUER P220 as my primary sidearm in uniform duty, SWAT, plainclothes and off-duty since 1992, because I felt the SIG .45 was the most reliable replacement available for the stalwart S&W Model 28, which I had to relinquish when my department mandated a switch to semiauto pistols.
The Sig Pro is one of them, although its decocking-lever spring is part of its fire-control unit and not separate as it is in the P220 and P229.