CDKN2A

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CDKN2A

A gene on chromosome 9p21 that encodes an alternate open reading frame (ARF) product, which acts as a tumour suppressor by binding to MDM2 and blocking its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits MDM2’s oncogenic activity, which would normally degrade p53, a tumour suppressor protein. CDKN2A also induces G2 arrest and apoptosis, independent of p53, by preventing the activation of cyclin B1/CDC2 complexes.

CDKN2A also binds to:
• BCL6, downregulating BCL6-induced transcriptional repression;
• E2F1 and MYC, blocking their transcriptional activator activity;
• HUWE1, repressing its ubiquitin ligase activity;
• TOP1/TOPOI, stimulating its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation.

CDKN2A interacts with:
• COMMD1 and promotes its “Lys63”-linked polyubiquitination;
• NPM1/B23, promoting its polyubiquitination and degradation and inhibiting rRNA processing;
• UBE2I/UBC9, enhacing sumoylation of some of its binding partners (e.g., MDM2 and E2F1).
References in periodicals archive ?
Ang opined that if PSALM really has basis on its claimed underpayments of P19 billion, then it may steadfastly turn in the basis of its calculations as well as corresponding evidence-documents as mandated by the Court.
BoB explains that account reconciliation is a process through which customers compares their records with a statement from their banker and that the figures mean a total of P2 274 266 757 was paid out by government while P19 660 376 833 was paid to, or received by government "therefore it is shocking that deposits of P19 660 376 833 are considered missing money".
Jane Thomson, chair of Prestwich Arts Festival, said: "There have been six local members of the community who have funded the materials and donated the cherry picker to make it happen, as well as Akse P19 donating his time for free.
A total of P4.435 million of the remaining P19.812 million was allocated for the financial assistance program for the personnel of the DND and its bureaus affected by Typhoon Yolanda, and the magnitude 7.2 earthquake in 2013.
"He met with the prison governor on Tuesday morning when he received a P19. He has lost any privileges he once had.
The Chirp brand is now P18.00 vs P16.00; Faber Castell P23.75 vs P19.75; Amspec P29.25 vs P28.75; and Mongol at P24.25.
Tenders reached P19.01 billion, more than three times larger than the P6 billion offer volume.
'For four consecutive weeks now, the average farm-gate price of palay at P18.98 per kilogram was still on a downtrend as it posted a 0.26-percent decline from previous week's level of P19.03 per kilogram,' the PSA said in its weekly report on palay, rice and corn prices, published recently.
The BTr said this was also due to the impact of currency fluctuations on both dollar and third-currency denominated debt amounting to P19.42 billion and P8.38 billion, respectively.
Emmerdale's Matthew Wolfenden is well groomed for marriage P4&5 Putting the birds and bees into your summer wardrobe P6&7 Blog on the Tyne and China P11&15 Shake up your gym routine for better results P18 Steve Hendry's views and the best of this week's TV pickings STARTS P19 We take a look ahead to next weekend with the best of T in the Park Global dance stars Slam on their T in the Park highlights P2&3 What's hot and not in movie and DVD world P4&5 New York rapper Nas is still at the top of his hip hop game P8&9 Bassist Peter Hook hits out at T stars New Order P10&11 Why Frisky and Mannish couldn't miss T in the Park P12&13 7 questions with Kaisers' Ricky Wilson P14&15 Fab contests, crossword and puzzles STARTS P28
February 25-March 2, 2012 WIN P19 GP26N TIN SGSGSGSGSGS P CONTENTSCONTENTST P LISTINGS G FUN P55 FEATURES P4-7 REAL LIFE P9 SOAPS P12-17 S MOVIES P23 telly We love t Supplements Editor: Tony Stewart Chief Sub-Editor: Ian Sturgess Features Editor: Jennifer Rodger Feature Writer: Sara Wallis Art Editor: Jason Gray Art Director: Annie Roth Picture Editor: Kirsty Barclay Assistant Picture Editor (Research): Joanna Hargreaves TV Listings Editor: Ed Keenan Colour correction: Mirror Image Quality Dept We Love Telly is published by MGN Ltd [umlaut] MGN Ltd.
LT Group sets P19 B capex for 2019 !-- -- Iris Gonzales (The Philippine Star) - May 9, 2019 - 12:00am MANILA, Philippines LT Group Inc., the listed conglomerate of taipan Lucio Tan, is pouring in P19 billion for capital expenditures this year, higher than 2018's P11 billion.