CDKN2A

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CDKN2A

A gene on chromosome 9p21 that encodes an alternate open reading frame (ARF) product, which acts as a tumour suppressor by binding to MDM2 and blocking its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits MDM2’s oncogenic activity, which would normally degrade p53, a tumour suppressor protein. CDKN2A also induces G2 arrest and apoptosis, independent of p53, by preventing the activation of cyclin B1/CDC2 complexes.

CDKN2A also binds to:
• BCL6, downregulating BCL6-induced transcriptional repression;
• E2F1 and MYC, blocking their transcriptional activator activity;
• HUWE1, repressing its ubiquitin ligase activity;
• TOP1/TOPOI, stimulating its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation.

CDKN2A interacts with:
• COMMD1 and promotes its “Lys63”-linked polyubiquitination;
• NPM1/B23, promoting its polyubiquitination and degradation and inhibiting rRNA processing;
• UBE2I/UBC9, enhacing sumoylation of some of its binding partners (e.g., MDM2 and E2F1).
References in periodicals archive ?
Sbyke comes in three models: A20 ($99), P16 ($149), and P20 ($249).
ELECTRIC CINEMA Station St, Birmingham, 0121 643 7879, www.theelectric.co.uk Alan Partridge - Alpha Papa (15): See review p16. Kick-Ass 2 (15): See review p16.
Airex (Somersworth, NH) has introduced its P16 Linear Motor.
The main focus has been to determine the patterns of molecular level alterations in p16 gene in human ovarian cancers to explore the possibilities of identifying potential biomarker in blood which could help in clinical practice as a diagnostic and prognostic marker.
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investigated the correlation links between expression level of protein p53, p21(WAF1/CIP1), p16 (INK4) and proliferative potential in human endometrial adenocarcinoma (EC).
They analyzed the behavior of two tumor-suppressing genes, p16 and FHIT, that are silenced or damaged in the early stages of cancer development, and tracked whether the genes were silenced by methylation, the attachment of a chemical methyl group to an atom or molecule, which in this case, eventually leads to the function of a gene shutting down.
-- Recommend p16 mutation genetic testing only in patients with multiple primary melanomas or a family history that includes multiple cases of melanoma or pancreatic cancer, Dr.
Methods: Promoter hypermethylation analysis of five tumour associated genes namely p16, p15, MGMT, hMLH1 and E-cadherin were done for 41 MDS patient samples with its various subtype.
For example, hypermethylation in the promoter region and silencing of p16 tumor suppressor gene are frequently observed during carcinogenesis that can occur on a background of global DNA hypomethylation (Wu et al.
We performed LightCycler PCR studies on human tumor DNA samples for the precise quantification of allelic imbalances of the human tumor suppressor genes p53 and p16, as well as the oncogene ErbB-2.
The patent covers the composition of matter of the full-length protein produced by the p16 tumor suppressor gene and antibodies against the p16 protein.