P-selectins


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P-selectins

An adhesion receptor molecule for white blood cells that functions during inflammation and tissue repair. Binding with P-selectin glycoprotein ligand 1, it controls the flow of white blood cells and their adhesion to blood vessel walls. It is viewed as a key factor in thrombosis.
See also: selectin
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Rabbit interleukins (IL-1, IL-2, IL-6, IL-7, IL8, and IL-18), ICAM-1, VCAM-1, CRP, TNF-[alpha], and P-selectin kits were purchased from Cusabio (China).
Serum IL-1, IL-2, IL-6, IL-7, IL-8, and IL-18, ICAM-1, VCAM-1, CRP, TNF-[alpha], and P-selectin were evaluated using the Cusabio (Hubei Province, China) ELISA kits.
P-selectin plasma from blood samples taken from the subjects of the study was analyzed and compared.
A set of P-selectin was purchased from Randox Laboratories Limited (UK).
On the other hand, the LFD group showed higher levels of P-selectin (P = 0.03) at 5 years of dietary intervention.
The longest selectin molecule with 9 such motifs is P-selectin and it was named based on its first recognized source, the platelets.
There is considerable difference in the cellular appearance of these selectins not only in the sense that P-selectin is not cell-specific, as it is present on both platelets and endothelial cells, but also regarding its appearance in normal or activated cells [1, 2].
Adhesion molecules involved in the recruitment of leukocytes include L-selectin, P-selectin, and E-selectin, which interact with P-selectin glycoprotein ligand 1 (PSGL1), as well as other glycosylated ligands, for example, intercellular adhesion molecule 1 (ICAM1) and vascular cell-adhesion molecule 1 (VCAM1) [6].
Nasal polyp tissues showed higher gene expression levels of the adhesion molecules P-selectin (1.62-fold, n = 7), PSGL1 (1.74-fold, n = 7), and VCAM1 (2.16-fold, n = 7) compared to associated inferior turbinates (Figure 1(a)).
One type of adhesion molecule that is affected by the alcohol ingestion is P-selectin."
Conradt et al., "Circulating vascular cell adhesion molecule-1 correlates with the extent of human atherosclerosis in contrast to circulating intercellular adhesion molecule-1, E-selectin, P-selectin, and thrombomodulin," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Blann, "Sex differences in circulating P-selectin, E-selectin and thrombomodulin," The British Journal of Haematology, vol.