P-glycoprotein

(redirected from P-glycoproteins)

glycoprotein

 [gli″ko-pro´tēn]
any of a class of conjugated proteins consisting of a compound of protein with a carbohydrate group.
α1-acid glycoprotein an acute phase protein found in blood plasma, an indicator of tissue necrosis and inflammation. Called also orosomucoid.
P-glycoprotein a cell-surface protein occurring normally in the colon, small intestine, adrenal glands, kidney, and liver, and also expressed by tumor cells. It is a modulator of multidrug resistance, mediating the transport of antineoplastic agents out of tumor cells.
variable surface glycoprotein any of several glycoproteins that form the antigenic protein coating of Trypanosoma brucei. The organisms contain numerous genes encoding hundreds of such glycoproteins and, by expressing individual ones successively, evade the immune system of the host.

P-gly·co·pro·tein

(glī'kō-prō'tēn),
Protein associated with tumor multidrug resistance; acts as energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.
Synonym(s): P-170

P-gly·co·pro·tein

(glī'kō-prō'tēn)
Protein associated with tumor multidrug resistance; acts as an energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.

P-glycoprotein

A cell membrane pump that influences cellular uptake and release of chemicals. It affects the relative resistance or susceptibility of cells to drug therapy.
See also: glycoprotein
References in periodicals archive ?
Its phytochemicals have gained much attention in recent years because of their obvious effect against p-glycoproteins and as a detoxifying agent (Meghwal and Goswami, 2013).
Cannon and his NIEHS colleagues initially found that amitriptyline significantly reduced P-glycoproteins pump activity in brain capillaries from wild-type rats.
The aim of the present investigation was, firstly, to investigate whether or not tumor cells specifically over-expressing ABCB1- and ABCB5-type P-glycoproteins are cross-resistant to (-)-sesamin.
P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: Prospects for reversing transport-dependent anthelmintic resistance.
It is also well-known that one of the main mechanisms underlying drug resistance is based on the expression of MDR-l gene which leads to the formation of membrane-bound ABC transporter proteins, such as P-glycoproteins (16), (17).
Concise guide to drug interaction principles for medical practice: cytochrome P450s, UGTS, p-glycoproteins. Washington, DC: American Psychiatric Press, Inc; 2003.
But two additional results were quite worrying: Good bacteria in the intestines were dramatically reduced--by 50 percent!--while P-glycoproteins were increased, a condition that limits the absorption of oral drugs." HSI (Health Sciences Institute of Baltimore) report sent Oct.
Another useful effect of this agent is the inhibition of P-glycoproteins by its metabolites (10).
A certain group of Transport proteins, the P-glycoproteins, have been shown to effect the delivery of some drugs to cancer cells.
Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem 1990;265:506-14.
Most people don't talk about their p-glycoproteins, but everybody's got them.
Werbeloff (2001) explains that phase 1 involves the action of cytochrome P450 and P-glycoprotein which remove toxic substances that if not cleared will often manifest as an external skin condition.